Arizona Cardinals vs Seattle Seahawks NFL Prediction & Best Bets | Sharp Money Analysis for Week 10

Here’s what’s interesting about this Week 10 matchup — we’ve got two teams heading in completely different directions, but the betting market might be missing something crucial. The Seahawks are riding high after dismantling Washington 38-14 on Sunday Night Football, while Arizona just knocked off Dallas 27-17 on Monday night.

For newcomers to NFL betting, this is a perfect game to understand how recent performance can create betting value. When one team looks dominant and another seems inconsistent, the public often overreacts. Smart bettors know to dig deeper into the numbers and situational spots.

The key storyline here is whether Seattle can maintain their offensive explosion at home, or if Arizona’s sneaky-good road record continues. Both teams are fighting for NFC West positioning, making this more than just a regular divisional matchup.

Game Details Box

Date: Sunday, November 9
Time: 4:05 PM ET
Location: Lumen Field, Seattle
TV: CBS

Current Betting Lines

Quick Translation: Seattle needs to win by 7+ points to cover the spread. The total means you’re betting whether both teams combine for more or less than 45.5 points. The moneyline shows Seattle as heavy favorites — you’d need to bet $330 to win $100 on them, while a $100 bet on Arizona pays $265.

Line Movement Analysis

The market is holding around Seahawks -6.5 with a total near 45.5. That’s consistent with Seattle’s top-5 scoring profile and Arizona’s strong time-of-possession game that can shorten contests.

Key Matchups

The central hinge is Seattle’s passing efficiency against Arizona’s secondary. Jaxon Smith-Njigba leads the NFL with 948 receiving yards and has four straight 100-yard games. Seattle as a team is elite by efficiency through the air — 9.5 yards per pass (No. 1) — while Arizona allows 231.8 passing yards per game (No. 23) but keeps yards-per-attempt reasonable.

Quarterback play matters here too. Sam Darnold threw four first-half touchdowns in the 38–14 win over Washington, and Seattle’s red-zone finish rate sits at 70.37% (No. 3). Arizona’s defense ranks 22nd in third-down conversion rate allowed at 41.2%, which can be a problem against a balanced attack.

Why Smart Bettors Like Arizona

• Road Warriors — 4–0 ATS on the road (confirmed).
• Competitive Gene — Multiple close losses (confirmed profile), not getting blown out.
• Divisional Spot — Familiar opponent in a divisional game tends to compress margins.

Betting Recommendations

Primary Bet: Arizona Cardinals +6.5 (-110) — Seattle’s home form and scoring are real, but 6.5 is a hefty ask against a road team that’s been covering consistently and can win the possession battle. Arizona’s offense converts at a high clip on third down (45.87%, No. 4), which helps them stick around the number.

Secondary Consideration: Under 45.5. Both teams flashed offense in primetime, but divisional November games often play tighter. Seattle runs often (49.67% rush rate, No. 2) but at just 3.7 YPC (No. 31), and Arizona can bleed clock (TOP% 53.13%, No. 4).

What to Watch For

• Live-bet windows if Arizona scores first — spreads can tighten quickly at Lumen Field.
• Kyler Murray’s mobility — any limitation swings leverage to Seattle’s pass rush lane discipline.
• Weather/wind — notable breeze at Lumen dings explosives and field goals.
• Seattle’s early scripts — if they start slow again, the live +7.5/+8 becomes attractive.

Bottom Line Summary

Seattle likely wins, but the spread looks inflated off recent blowout optics. Arizona’s validated road ATS record and possession game profile make them a live divisional underdog catching nearly a touchdown.

Final Score Prediction: Seahawks 24, Cardinals 21.