Saints vs Panthers Week 10 Picks & Odds

by | Nov 6, 2025 | nfl

Nov 2, 2025; Inglewood, California, USA; New Orleans Saints quarterback Tyler Shough (6) hands off to running back Alvin Kamara (41) during the second half against the Los Angeles Rams at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Saints vs Panthers Preview: Week 10 NFC South Free Pick ATS

Opening Setup

Here’s what you need to know about Sunday’s NFC South showdown between New Orleans and Carolina. The Saints are limping into Charlotte at 1-8, riding a four-game losing streak that has them looking more like a draft lottery team than a playoff contender. Meanwhile, the Panthers have quietly turned into one of the NFL’s better bets, going 6-3 against the spread while sitting at 5-4 straight up.

For newer bettors, this is a perfect example of why records don’t tell the whole story. Carolina opened the season with a 6.5 win total, and most folks figured they’d be playing spoiler by November. Instead, they’re chasing a playoff spot and getting respect from the betting market as 5-point home favorites.

The key storyline here is momentum versus desperation. Carolina just shocked Green Bay as 13.5-point road underdogs, with Rico Dowdle running for 130 yards and two touchdowns. New Orleans, meanwhile, is starting rookie Tyler Shough at quarterback after cycling through what feels like half the league at the position this season.

Game Details Box

Date: Sunday, November 9
Time: 1:00 PM ET
Location: Bank of America Stadium, Charlotte
TV: FOX

Current Betting Lines

Bet Type Line Juice
Point Spread Panthers -5 -110
Total Points Over/Under 40 -110
Moneyline Panthers -250 / Saints +210

Quick Translation: Carolina needs to win by 6+ points to cover the spread. The total means both teams need to combine for 41+ points to hit the over. The moneyline shows the Panthers are heavy favorites – you’d risk $250 to win $100 on Carolina, while a $100 bet on New Orleans pays $210.

Line Movement Analysis

The line opened with Carolina favored by 4.5 points and has moved to 5, indicating sharp money is backing the Panthers despite their underdog narrative. This is what we call “market respect” – when oddsmakers and professional bettors start believing in a team regardless of their reputation. The total has stayed steady around 40, suggesting both offensive units are viewed as limited. When you see minimal movement on a total this low, it usually means the market has found the right number quickly.

Key Matchups

The biggest mismatch is Carolina’s ground game against New Orleans’ run defense. The Saints are allowing 129.4 rushing yards per game and 4.0 yards per carry, while Dowdle just torched Green Bay for 130 yards on 25 attempts. Carolina ranks 5th in rushing offense at 139.8 yards per game, and they’ve found their identity running behind this improved offensive line.

On the flip side, both passing attacks are struggling mightily. New Orleans ranks 22nd in passing offense at 197.6 yards per game, while Carolina sits 30th at 170.9 yards per game. With rookie Shough making his second start for the Saints and Bryce Young still inconsistent for the Panthers, this game screams ground-and-pound.

Why Smart Bettors Like Carolina

  • Momentum and Confidence — Stunning upset win at Lambeau builds belief in locker room.
  • Home Field Advantage — Panthers are 3-1 ATS at home, finding their identity in Charlotte.
  • Rushing Attack Advantage — Dowdle handled 25 carries to Hubbard’s 5 at Green Bay.

Betting Recommendations

Primary Bet: Panthers -5 (-110) — The Saints are in full collapse mode, getting outscored 108-46 over their last four games with a point differential of -105 for the season. Carolina has the better quarterback situation, the superior ground game, and the confidence from their Green Bay upset. This feels like a spot where the Panthers pull away in the second half against a demoralized Saints team.

Secondary Consideration: Under 40 total. Both offenses rank in the bottom third of the league, and with game flow likely favoring Carolina’s running attack, the clock should move quickly in the second half.

What to Watch For

  • Early game script – if Panthers jump ahead, Saints lack offensive weapons to catch up
  • Dowdle’s workload — he logged 25 carries at Green Bay; if that volume holds, Carolina can stay on schedule
  • Saints’ quarterback situation – any late changes or early struggles from Shough
  • Weather conditions – could impact the under if conditions deteriorate

Bottom Line Summary

This line represents the market finally acknowledging what the numbers have been saying for weeks – Carolina is a competent football team while New Orleans is in shambles. The Saints are 2-7 ATS this season, the worst mark in the NFL, while the Panthers are 6-3 ATS and finding ways to exceed expectations. Sometimes the obvious play is the right play.

Final Score Prediction: Panthers 21, Saints 16.

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