The St. Louis Cardinals (75-69) head to the Pacific Northwest to face the red-hot Seattle Mariners (77-66) in an interleague showdown at T-Mobile Park. This matchup features a significant pitching disparity with Seattle’s Bryan Woo looking to continue his impressive season against a struggling Miles Mikolas. The Mariners are coming off a dominant offensive explosion in Atlanta, dropping 18 runs on the Braves, while fighting to maintain their Wild Card position against the charging Kansas City Royals. With Seattle’s offense clicking and their ace on the mound, this Monday night matchup presents several intriguing betting angles.
Quick Picks:
- Best Bet: Seattle Mariners -1.5 (-105) ★★★★☆
- Top Prop: Cal Raleigh Over 1.5 Hits+Runs+RBIs (-135) ★★★★☆
- Value Play: Bryan Woo Over 6.5 Strikeouts (-120) ★★★☆☆
Cardinals vs Mariners Betting Odds & Latest Line Movement
| Market | St. Louis Cardinals | Seattle Mariners |
|---|---|---|
| Moneyline | +180 | -220 |
| Run Line | +1.5 (-115) | -1.5 (-105) |
| Total | Over 7.5 (-110) | Under 7.5 (-110) |
Opening Line: Mariners -215, Total 7.5
Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers
The line has seen minimal movement since opening, with the Mariners holding steady around -220 on the moneyline. This stability suggests balanced action from professional bettors despite the significant pitching mismatch. The most notable betting signal is on the run line, where I’m seeing sharper money come in on Seattle -1.5 at nearly even money (-105). With the Mariners’ recent offensive explosion and their ace on the mound, professional bettors appear comfortable backing them to win by multiple runs against a Cardinals team that’s been inconsistent on the road.
Pitching Matchup: Miles Mikolas vs Bryan Woo – Who Has the Edge?
St. Louis Cardinals: Miles Mikolas (7-10, 4.89 ERA)
- Has allowed 4+ earned runs in 4 of his last 7 starts
- 136.1 innings pitched with mediocre 4.89 ERA and 1.33 WHIP
- Low strikeout rate (86 Ks in 136.1 IP) leaves him vulnerable to contact
- BB/K ratio of 33/86 shows decent control but limited swing-and-miss stuff
Seattle Mariners: Bryan Woo (12-7, 3.02 ERA)
- Enjoying a breakout season with excellent 3.02 ERA across 169.2 innings
- Outstanding 169 strikeouts against just 34 walks (5:1 K/BB ratio)
- Elite 0.97 WHIP ranks among the best in baseball
- Has been especially dominant at pitcher-friendly T-Mobile Park
Advantage: Significant edge to Seattle. Woo has been among the most efficient and effective starters in the American League, while Mikolas has struggled with consistency all season.
Bullpen Breakdown
The Mariners hold a clear advantage in the bullpen department as well. Seattle features one of the league’s most reliable closers in Andrés Muñoz (32 saves) and a strong setup corps including Matt Brash, Gabe Speier, and Luke Jackson. Their combined 3.44 bullpen ERA ranks 5th in MLB, while maintaining one of the lowest BAA at .222. The Cardinals’ relief corps has been much more volatile, relying heavily on JoJo Romero (7 saves, 21 holds) and a collection of less consistent arms. With T-Mobile Park’s pitcher-friendly confines, the Mariners’ bullpen advantage becomes even more pronounced if this game stays close into the later innings.
Key Betting Trends & Team Statistics That Matter
- Seattle is 25-15 in their last 40 home games, showing strong performance at T-Mobile Park
- The Mariners have scored 28 runs in their last two games after a brief offensive slump
- St. Louis is just 34-36 in road games this season, struggling to find consistency away from Busch Stadium
- The Cardinals are 6-12 in interleague play in 2025, showing difficulty against AL competition
- Bryan Woo is 8-2 with a 2.71 ERA in 11 home starts this season
- Miles Mikolas has a 5.31 ERA in road starts this season
- Seattle is 39-21 when facing right-handed starting pitchers at home
Cal Raleigh: Seattle’s Power-Hitting Catcher Chasing History
Cal Raleigh continues his historic season, now sitting at 53 home runs on the year – just one behind Mickey Mantle’s record for most home runs by a switch-hitter in a single season. The “Big Dumper” has been a revelation for Seattle, providing consistent power from the catcher position while guiding one of baseball’s best pitching staffs. Against Mikolas, who has surrendered 25 home runs this season, Raleigh presents a matchup nightmare. His patient approach (drawing 72 walks this season) combined with his power stroke makes him one of the most dangerous hitters in this lineup and a prime candidate to continue his historic season tonight.
T-Mobile Park Factor: How the Venue Influences Today’s Game
T-Mobile Park ranks as the most pitcher-friendly venue in baseball this season with a run factor of just 0.843 and a home run factor of 0.894. This setting greatly favors Bryan Woo’s pitching style, as his outstanding command and swing-and-miss stuff plays up even further in the spacious dimensions. For Mikolas, who relies on contact management rather than strikeouts, this park provides little margin for error against a Seattle lineup that ranks 4th in MLB in home runs. The evening conditions in Seattle typically feature cooler temperatures and heavier air, which should further suppress offense and benefit Woo’s approach. If there’s any silver lining for Cardinals hitters, it’s that the park plays more neutral for right-handed power, which could benefit some of their right-handed bats.
Expert Prediction & Best Bets for Cardinals-Mariners Showdown
Primary Play: Seattle Mariners -1.5 (-105)
I’m strongly backing the Mariners on the run line tonight. The pitching mismatch is substantial, with Woo’s elite command and strikeout ability giving Seattle a massive edge over the contact-dependent Mikolas. The Mariners’ offense has erupted for 28 runs in their last two games, and they’re returning home where Woo has been exceptional (8-2, 2.71 ERA). With Seattle’s superior bullpen and the Cardinals’ struggles on the road and in interleague play, I expect the Mariners to win comfortably by multiple runs. At nearly even money, the run line provides excellent value.
Strong Value Play: Cal Raleigh Over 1.5 Hits+Runs+RBIs (-135)
Raleigh is in the midst of a historic power season and draws a favorable matchup against Mikolas, who has surrendered 25 home runs this season. The Cardinals’ starter has particularly struggled against left-handed power, and Raleigh’s switch-hitting ability means he’ll have the platoon advantage. With Raleigh sitting just one homer away from tying Mickey Mantle’s switch-hitter record, he’ll be locked in at the plate. Even if he doesn’t homer, Raleigh has been getting on base consistently and should easily clear this total with a walk and a hit or via an RBI opportunity with runners on base.
Worth Considering: Bryan Woo Over 6.5 Strikeouts (-120)
Woo has been a strikeout machine this season with 169 Ks in 169.2 innings. The Cardinals rank middle of the pack in strikeout rate against right-handed pitching, and Woo’s swing-and-miss stuff should play up at T-Mobile Park. With St. Louis unfamiliar with Woo’s repertoire in this interleague matchup, I expect him to record at least 7 strikeouts in what should be a quality start. His command has been exceptional (just 34 walks all season), allowing him to work deep into games and accumulate strikeouts.
Player Props Worth Targeting in Today’s Matchup
| Player | Prop | Odds | Rating |
|---|---|---|---|
| Cal Raleigh | Over 1.5 Hits+Runs+RBIs | -135 | ★★★★☆ |
| Bryan Woo | Over 6.5 Strikeouts | -120 | ★★★☆☆ |
| Julio Rodriguez | Over 1.5 Total Bases | -115 | ★★★★☆ |
| Jorge Polanco | Over 0.5 Total Bases | -170 | ★★★☆☆ |
Final Thoughts: Mariners’ Momentum Continues in Seattle
Everything points to a Mariners victory tonight. Seattle’s offense is clicking at the perfect time as they fight to hold off Kansas City for the final Wild Card spot. Bryan Woo has been exceptional all season, especially at home, while Miles Mikolas has struggled with consistency and keeping the ball in the park. The Mariners’ pitching advantage extends to the bullpen, where they have several reliable arms to close out games. Add in T-Mobile Park’s pitcher-friendly dimensions that will amplify Woo’s strengths, and we have a perfect setup for Seattle to win comfortably. I expect the Mariners to continue their offensive momentum while Woo limits the Cardinals’ opportunities.
Score Prediction: Seattle Mariners 6, St. Louis Cardinals 2
