Cubs vs Reds Prediction & Best Bets | Lefty Duel at Great American Ball Park

by | Sep 19, 2025 | mlb

Cubs vs Reds Prediction & Best Bets | Lefty Duel at Great American Ball Park

The Chicago Cubs (88-65) head to Cincinnati to face the Reds (77-76) in what promises to be an intriguing pitching matchup between two impressive left-handers. Shota Imanaga and Nick Lodolo sport nearly identical ERAs, but the Cubs’ superior offensive and defensive metrics give them a slight edge in this NL Central showdown. With Chicago fighting to secure their playoff position and Cincinnati clinging to slim postseason hopes, this Friday night matchup at the hitter-friendly Great American Ball Park offers several compelling betting angles worth targeting.

Quick Picks:

  • Best Bet: Chicago Cubs ML (-125) ★★★★☆
  • Top Prop: Pete Crow-Armstrong Over 1.5 Total Bases (+135) ★★★★☆
  • Value Play: First 5 Innings Under 4.5 (+100) ★★★☆☆

Chicago Cubs vs Cincinnati Reds Betting Odds & Latest Line Movement

Market Chicago Cubs Cincinnati Reds
Moneyline -125 +105
Run Line -1.5 (+135) +1.5 (-160)
Total Over 8.5 (-105) Under 8.5 (-115)

Opening Line: Cubs -125, Total 8.5

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

The line movement has been minimal in this matchup, suggesting a fairly balanced action from both recreational and professional bettors. The Cubs opened as slight -125 favorites and have remained in that range, indicating the market views this as a relatively even contest despite Chicago’s superior record. What’s particularly interesting is the slight juice move toward the under, suggesting some sharp money believes the left-handed starters might have more success than the hitter-friendly park would typically indicate. I’m seeing some professional resistance to the total, which is noteworthy given Great American Ball Park’s reputation as one of the most homer-friendly venues in baseball.

Pitching Matchup: Shota Imanaga vs Nick Lodolo – Who Has the Edge?

Chicago Cubs: Shota Imanaga (9-7, 3.29 ERA)

  • Outstanding 0.95 WHIP ranks among the league’s best
  • Exceptional control with just 23 walks in 134.0 innings
  • Has pitched well on the road with a 3.42 ERA away from Wrigley
  • Induces weak contact with only 0.94 HR/9 despite 134 innings pitched

Cincinnati Reds: Nick Lodolo (8-8, 3.30 ERA)

  • Impressive 1.04 WHIP shows his command and control
  • Strong K/BB ratio with 137 strikeouts to just 26 walks in 144.2 innings
  • Has been better at home (2.87 ERA) than on the road (3.73)
  • Has struggled against right-handed power hitters, which could be problematic against Cubs lineup

Advantage: Slight edge to Imanaga. While their ERAs are nearly identical, Imanaga’s superior WHIP and better command give him a small advantage. Both lefties have been impressive, but Imanaga’s ability to limit baserunners could be decisive in a hitter’s park.

Bullpen Breakdown

The Cubs hold a distinct advantage in the bullpen battle. Chicago’s relief corps has been steady and reliable, with Daniel Palencia (22 saves) establishing himself as a dependable closer. The Cubs have built bullpen depth with solid contributors like Brad Keller (25 holds), Caleb Thielbar, and Andrew Kittredge providing quality bridge innings. On the Cincinnati side, while Emilio Pagán (27 saves) has been a bright spot, the overall depth isn’t as impressive. Tony Santillan has emerged as a reliable setup man with 29 holds, but the Reds have had to rely more heavily on fewer arms. In a potentially close game that could come down to the late innings, Chicago’s deeper and more reliable bullpen gives them a significant edge if the starters exit with a close score.

Key Betting Trends & Team Statistics That Matter

  • Cubs have a significant +132 run differential compared to Cincinnati’s +27
  • Chicago’s offense averages 4.86 runs per game vs. Cincinnati’s 4.46
  • Cubs have been stronger in close games (55.6% win rate) than the Reds (47.8%)
  • Great American Ball Park ranks 4th in home run factor (1.384) this season
  • Cubs defense commits fewer errors per game (0.39) than the Reds (0.57)
  • Chicago has won 5 of the last 9 meetings against Cincinnati this season
  • Cubs are 66-37 when favored this season, a 64.1% win rate
  • Reds are just 39-42 as underdogs, winning at a 48.1% clip

Pete Crow-Armstrong’s Power Surge: Cubs’ Outfielder Finding His Groove

Pete Crow-Armstrong has developed into one of Chicago’s most dangerous hitters with his combination of power and speed. His season numbers (.246 BA, 29 HR, 37 doubles) don’t fully capture his recent surge, as he’s been particularly hot over the last two weeks with 4 homers and 9 RBIs. What makes this matchup particularly interesting is that despite Lodolo’s overall effectiveness, he’s shown vulnerability against right-handed power hitters who can turn on inside fastballs. Crow-Armstrong fits this profile perfectly and could be primed for a big game in the homer-friendly confines of Great American Ball Park. His total bases prop deserves serious consideration given the matchup advantages.

Great American Ball Park Factor: How the Venue Influences Today’s Game

Great American Ball Park ranks as one of the most hitter-friendly venues in baseball, particularly for home runs. With a home run factor of 1.384 (4th highest in MLB) and a runs factor of 1.093, this park significantly boosts offensive production. The right field porch is particularly inviting for left-handed pull hitters, which could benefit Cubs’ lefty sluggers. However, it’s worth noting that both starting pitchers have demonstrated ability to keep the ball in the park, with Imanaga (0.94 HR/9) and Lodolo (1.12 HR/9) both showing above-average skill at limiting long balls. The park dimensions remain a significant factor, but with two control-oriented lefties on the mound, we might see more of a pitcher’s duel than the venue would typically suggest. That said, any mistake pitches are more likely to leave the yard here than in most parks.

Expert Prediction & Best Bets for Cubs-Reds Showdown

Primary Play: Chicago Cubs Moneyline (-125)

I’m backing the Cubs on the moneyline as my primary play. Chicago has numerous advantages that make them worth the price – a superior bullpen, better defensive metrics, and a more potent offense. While Lodolo has been solid at home, the Cubs’ right-handed power bats match up well against him. The Cubs have also performed significantly better as favorites (66-37) than the Reds have as underdogs (39-42). At this modest price, Chicago represents solid value, and I’d play them up to -135.

Strong Value Play: First 5 Innings Under 4.5 (+100)

Despite the hitter-friendly venue, I expect both Imanaga and Lodolo to deliver quality starts. Both lefties feature excellent control, limit hard contact, and have been consistently effective all season. The first five innings should feature a more controlled, lower-scoring environment before the bullpens get involved. With two pitchers sporting nearly identical 3.30 ERAs and both ranking in the top tier for WHIP, getting even money on the F5 under 4.5 offers tremendous value.

Worth Considering: Pete Crow-Armstrong Over 1.5 Total Bases (+135)

Crow-Armstrong has been swinging a hot bat lately, and Great American Ball Park’s dimensions play perfectly to his strengths. While Lodolo is a quality pitcher, he’s shown vulnerability against right-handed power hitters, and Crow-Armstrong’s combination of extra-base power and speed makes this prop particularly attractive at plus odds. His ability to collect total bases through doubles and triples (not just homers) gives this bet multiple paths to victory.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Pete Crow-Armstrong Over 1.5 Total Bases +135 ★★★★☆
Nico Hoerner Over 1.5 Hits +165 ★★★☆☆
Shota Imanaga Over 5.5 Strikeouts -120 ★★★★☆
Elly De La Cruz To Record a Stolen Base +140 ★★★★☆
Ian Happ To Hit a Home Run +350 ★★★☆☆

Final Thoughts: Cubs’ Quality Should Prevail in Cincinnati

While this matchup features an intriguing lefty vs. lefty pitching duel with nearly identical ERAs, the Cubs’ advantages in multiple areas should be the difference. Chicago’s superior bullpen depth, defensive efficiency, and more potent offense give them a clear edge despite the challenging venue. The Cubs have consistently performed better in pressure situations all season, evidenced by their stronger record in close games. While Great American Ball Park’s homer-friendly dimensions always threaten to turn games into slugfests, both Imanaga and Lodolo have the command and control to keep things relatively in check. I expect the Cubs to grind out a close victory in a game that might start as a pitcher’s duel but could open up in the later innings.

Score Prediction: Chicago Cubs 5, Cincinnati Reds 3

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