MLB Picks: Cardinals vs. Giants 5/6/22

by | Last updated May 6, 2022 | mlb

St. Louis Cardinals vs San Francisco Giants

Date: Friday, May 6th, 10:15 ET

Location: Oracle Park

TV: Bally Sports Midwest Extra

Money Line: Cardinals -109 / Giants +101 (Pinnacle – Lowest betting odds around, however, they don’t accept USA bettors.)

Total Line: 7


St. Louis: Jordan Hicks (1-2, 3.65)
San Francisco: Alex Cobb (1-1, 5.4)

Cardinals Projected Lineup

C Yadier Molina
SS Paul DeJong
LF Corey Dickerson
CF Harrison Bader
RF Dylan Carlson
LF Tyler O’Neill
3B Nolan Arenado
2B Tommy Edman
1B Paul Goldschmidt

Giants Projected Lineup

P Luis Gonzalez
3B Jason Vosler
LF Darin Ruf
2B Thairo Estrada
C Joey Bart
1B Wilmer Flores
SS Brandon Crawford
CF Mike Yastrzemski
LF Joc Pederson


St. Louis Cardinals: 14-10-0 SU / OU 13-11-1 / Run Line W/L 14-11-0
San Francisco Giants: 14-10-0 SU / OU 12-12-1 / Run Line W/L 12-13-0

The San Francisco Giants host the St. Louis Cardinals on Friday, May 6th at Oracle Park. The first pitch in this matchup is scheduled for 10:15 ET. The MLB Odds Board places Cards as the favorite (-109), with an OU line set at 7.

Recent Form

The St. Louis Cardinals will look to pick up another big win, after they defeated the SF Giants by a score of 7-1. Overall, the team’s pitching staff limited the SF Giants to 1 runs on 10 hits. The Cardinals benefited from an offense that generated 7 runs on 12 hits. Heading into this game, St. Louis was the betting favorite, at -101.0. Through 16 games as the favorite, the team has found the win column at a rate of 69.0%. With the OU line set at 7.5 runs, the Cardinals and SF Giants combined to go over this total. So far, St. Louis has an above .500 OU record of (13-11-1).

The Cardinals come into this game with a 4-1 record of their last 5 contests. This record has come on an average scoring differential of 13. A key to their recent success has been an offense averaging 5.2 runs per game compared to their season average at 4.32. So far, St. Louis has won over half of their 9 series played, going 6-1-2.

San Francisco is coming off a -6 loss to St. Louis. Dropping the game (7-1). On their way to giving up 7 runs, the Giants staff allowed 12 hits. In the loss, the Giants’ offense still came up with 10 hits and 7 runs. Leading into the game, San Francisco was the betting favorite at -109.0. For the season, the team has been favored in 19 games, winning at a rate of 68.0%. In terms of the over-under, the Giants and St. Louis combined to surpass the line of 7.5 runs. This outcome moves the team’s over-under record back to .500 at 12-12-1.

The Giants come into today’s game looking to turn things around, as they are just 1-4 over their last 5 games. During this time, the team has a run differential of -16. If San Francisco is going to pick up their play, they need to improve their offensive performance. Over their last 5 contests, they are averaging just 3.4 runs per game, compared to a season average of 4.48. On the season, San Francisco has won more than half of their series, going 5-4-1.


Will Rodgers Sports HandicapperI won my last two MLB playoff picks and am going for three straight on Friday in Game 1 of the World Series! I had a sparkling run down the stretch (in the regular season), and look to finish in the same fashion in the postseason. Hop on board now!

Pitching Matchup

For the Cardinals, Jordan Hicks gets the start. So far, he has put together a record of 1-2. To date, Hicks has an ERA of 3.65, while lasting an average of 2.8 innings per appearance. Through 5 trips to the mound, opposing teams have combined for a batting average of 0.171. Not only does Hicks have a strong batting average allowed figure, but he has also avoided giving up home runs, averaging just 1 home run allowed per 9 innings pitched. Up to this point, Hicks has a strikeout percentage of 26.0% and a per 9 average of 2.6. Leading into the game, he has shown a strong command of his pitches, averaging just 5.84 walks per contest. For the Giants, Alex Cobb gets the start. So far, he has put together a record of 1-1. Leading up to the game, Cobb is hoping to bring down an ERA of 5.4. So far, he is averaging 3.33 innings per outing. Opposing lineups have put together a combined batting average of 0.311 against Cobb. Although opposing teams have been able to generate hits off him, Cobb has yet to give up a home run. Heading into today’s action, Alex Cobb is averaging 4.6 K’s per 9 innings. Throughout the season, his strong command has led to an average of just 4.5 walks per contest.

St. Louis vs San Francisco History

So far, the San Francisco Giants and St. Louis Cardinals have met up 1 time, with St. Louis leading the season series, 1-0. Through 1 game, the series’ over-under record is 1-0, with the average run total sitting at 7.0 runs per game. In these matchups, the average scoring differential sits at 6.0 runs. Going back to last year, St. Louis won the season series, 4 games to 2. In these 6 meetings, the two teams combined for an over-under record of 3-3. Last year, San Francisco and St. Louis averaged 7.0 runs per game. On average, the winning team won by a margin of 2.33 runs per contest.

Betting Trends

  • St. Louis is 4-1 SU in its last 5 games
  • The total has gone OVER in 4 of St. Louis’s last 5 games
  • The total has gone OVER in 5 of San Francisco’s last 6 games
  • The total has gone OVER in 5 of San Francisco’s last 6 games at home

St. Louis Cardinals at San Francisco Giants Prediction

I see this matchup between St. Louis and San Francisco ending in a low-scoring game, as Alex Cobb helps to get the Giants pitching staff back on track. On the other side, look for Jordan Hicks to continue his strong start to the season. Even with a record of just 1-2, opponents have had problems generating runs against the right-hander. Free Pick: Under 8 Runs. Make your MLB bets for FREE this weekend by scoring a 50% real cash bonus on your first deposit up to $500 at Bovada Sportsbook; home some of the fastest bitcoin payouts on the web and the absolute BEST live betting platform in the sports betting industry; bar none!

MLB Betting Guide

New to betting on baseball? We've got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!