Padres vs. Indians EARLY GAME 1 Odds & Pick

by | Last updated May 4, 2022 | mlb

San Diego Padres vs Cleveland Guardians

Date: Wednesday, May 4th, 01:10 ET

Location: Progressive Field

TV: Bally Sports San Diego

Money Line: Padres -125 / Guardians +105 (Bovada)

Total Line: OFF


San Diego: MacKenzie Gore (2-0, 1.76)
Cleveland: Cal Quantrill (1-1, 3.27)

Padres Projected Lineup

LF Jurickson Profar
SS Ha-seong Kim
1B Eric Hosmer
RF Matt Beaty
C Jorge Alfaro
3B Manny Machado
1B Jake Cronenworth
CF Trent Grisham
C Austin Nola

Guardians Projected Lineup

1B Josh Naylor
RF Oscar Mercado
SS Amed Rosario
1B Owen Miller
C Austin Hedges
3B José Ramírez
RF Franmil Reyes
CF Myles Straw
LF Steven Kwan


San Diego Padres: 15-8-0 SU / OU 10-13-0 / Run Line W/L 15-8-0
Cleveland Guardians: 10-12-0 SU / OU 12-10-0 / Run Line W/L 11-11-0

The Cleveland Guardians host the San Diego Padres on Wednesday, May 4th at Progressive Field. The first pitch in this matchup is scheduled for 01:10 ET. The MLB Odds Board places San Diego as the favorite (-125), with an OU line set at OFF.

Recent Form

The San Diego look to keep things rolling after taking down the Pittsburgh by the score of 5-2. On their way to the victory, the pitching staff game up 2 runs on 8 hits. The Padres benefited from an offense that generated 5 runs on 11 hits. Heading into this game, San Diego was the betting favorite, at -170.0. Through 17 games as the favorite, the team has found the win column at a rate of 76.0%. Combined, the Padres and Pittsburgh fell short of the over-under betting line of 7.5 runs. With this result, San Diego’s over-under record dropped even further, moving to just 10-13-0.

In the Padres’ last 5 games, they are above .500, going 4-1. During this time, they have an average scoring differential 11. Offensively, the team has put up 33 runs in their last 5 games. San Diego’s season averasge comes in at 4.74 (4th. So far, San Diego has won over half of their 7 series played, going 4-2-1.

The Cleveland Guardians are coming off a big win over Oakland by a score of 7-3. In the winning effort, the team’s pitchers held Oakland to 3 runs and 6 hits. At the plate, the Guardians scored 5 times on 9 hits. In the game, Cleveland was able to take care of business as they were the favorites at -118.0. For the season, the team has been favored in 8 games, winning at a rate of 75.0%. In terms of the over-under, the Guardians and Oakland combined to surpass the line of 7.0 runs. For the season, the team’s OU record is (12-10-0).

In their last 5 games, the Guardians have put together a record of 3-2. Cleveland has managed to play above .500 baseball, despite an even scoring differential. Offensively, Cleveland’s lineup has been steady 5.0 runs per game over their last 5 contests. For the season, the team comes in with a per-game average of 4.59. Cleveland has a below .500 series record of just 3-3-1.

Pitching Matchup

For the Padres, MacKenzie Gore gets the start. So far, he has put together a record of 2-0. Currently, Gore has a strong ERA of just 1.76, while pitching an average of 5.03 innings per outing. Across his previous starts, opposing teams have put together a batting average of 0.214. Despite opposing team’s finding success getting on base against Gore, he has managed to keep the ball in the ballpark, allowing 0.59 home runs per 9 innings. On the season, MacKenzie Gore has had no problem racking up strikeouts, posting a strikeout percentage of 32.3%, while averaging 12.0 K’s per 9 innings. Leading into the game, he has shown a strong command of his pitches, averaging just 2.0 walks per contest.

For the Guardians, Cal Quantrill gets the start. So far, he has put together a record of 1-1. Leading up to the game, Quantrill has an ERA of 3.27. So far, he is averaging 5.5 innings per outing. Opposing lineups have put together a combined batting average of 0.208 against Quantrill while up just 0.41 home runs per 9 innings. Heading into today’s action, Cal Quantrill is averaging 4.0 K’ per 9 innings. Throughout the season, walks have been an issue, as he is giving up 2.5 free passes per outing.

San Diego vs Cleveland History

Today’s matchup between the San Diego Padres and Cleveland Guardians will be their first meeting of the season.

More Picks: Rays vs. Athletics 5/4/22 Game Analysis & Free Moneyline Pick >>>

Betting Trends

  • Padres are 8-1 in their last 9 games as a favorite.
  • Padres are 8-1 in their last 9 vs. a team with a losing record.
  • Guardians are 17-38 in their last 55 interleague games vs. a team with a winning record.
  • Guardians are 4-9 in their last 13 home games, with the total set at 7.0-8.5.

San Diego Padres at Cleveland Guardians Prediction

Heading into this game, the Guardians are the 6th rated offensive unit at 4.59 runs per contest. In addition, their overall batting average is ranked 3rd at .251. Given that the Guardians are also the top-ranked scoring team against right-handed pitching look for the team to hand MacKenzie Gore his first loss. I recommend Cleveland on the moneyline.

Free Pick:

Cleveland ML

MLB Betting Guide

New to betting on baseball? We've got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!