Pirates vs Reds Moneyline Pick & Best Bets | MLB Predictions Sept 25

by | Sep 25, 2025 | mlb

Pirates vs Reds Prediction & Best Bets | Lodolo Looks to Continue Dominance at Great American

The Cincinnati Reds (82-75) look to strengthen their wild card position as they host the Pittsburgh Pirates (71-86) in Thursday’s early afternoon series finale at Great American Ball Park. This matchup features intriguing young pitchers with rookie Braxton Ashcraft showing impressive poise for Pittsburgh against Cincinnati’s Nick Lodolo, who’s been a model of consistency all season. With the Reds fighting for playoff positioning and the Pirates playing spoiler, this NL Central showdown offers several compelling betting opportunities that I’ve analyzed thoroughly.

Quick Picks:

  • Best Bet: Cincinnati Reds ML (-165) ★★★★☆
  • Top Prop: Nick Lodolo Over 6.5 Strikeouts (-115) ★★★★☆
  • Value Play: Over 8 Runs (-115) ★★★☆☆

Pittsburgh Pirates vs Cincinnati Reds Betting Odds & Latest Line Movement

Market Pittsburgh Pirates Cincinnati Reds
Moneyline +139 -165
Run Line +1.5 (-150) -1.5 (+130)
Total Over 8.0 (-115) Under 8.0 (-105)

Opening Line: Reds -160, Total 8.5

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

The line has seen minimal movement since opening, with Cincinnati remaining firmly in the -160 to -165 range despite receiving about 60% of public tickets. This stability suggests sharp money isn’t dramatically opposing the public perception here. What’s more interesting is the total dropping slightly from 8.5 to 8, which indicates some smart money respecting both starting pitchers despite Great American Ball Park’s reputation as a hitter-friendly venue. The run line juice at -150 for Pittsburgh +1.5 shows professionals are expecting a competitive game even with the Reds’ significant moneyline advantage.

Pitching Matchup: Braxton Ashcraft vs Nick Lodolo – Who Has the Edge?

Pittsburgh Pirates: Braxton Ashcraft (4-3, 2.62 ERA)

  • The rookie has been a bright spot for Pittsburgh with a stellar 2.62 ERA across 65.1 innings
  • Impressive 66:23 K:BB ratio showing good command for a young pitcher
  • WHIP of 1.19 indicates he’s limiting baserunners effectively
  • Has allowed two or fewer runs in 7 of his last 8 starts

Cincinnati Reds: Nick Lodolo (8-8, 3.44 ERA)

  • Consistent performer with 144 strikeouts in 149.1 innings pitched
  • Excellent control with just 28 walks all season (1.7 BB/9)
  • Elite 1.08 WHIP ranks among the best in the National League
  • Left-handed advantage against a Pirates lineup that struggles against southpaws (.229 team average vs LHP)

Advantage: Cincinnati. While Ashcraft has been impressive, Lodolo’s experience, superior strikeout rate, and exceptional command give him the edge, especially at home where he’s posted a 2.87 ERA this season.

Bullpen Breakdown

Cincinnati holds a clear advantage in the late innings with one of the more reliable bullpen units in the National League. Closer Emilio Pagán has been exceptional with 29 saves, while setup man Tony Santillan leads the league with 31 holds. The Reds bullpen features three relievers with 16+ holds, giving them multiple high-leverage options. Pittsburgh’s bullpen has been more vulnerable, with Dennis Santana (15 saves) serving as their primary closer but lacking the same depth of reliable setup options. The Pirates’ 4.35 bullpen ERA ranks in the bottom third of MLB, while Cincinnati’s 3.78 mark puts them in the top 10. With both starters typically working 6+ innings, this game could very well be decided by these relief corps.

Key Betting Trends & Team Statistics That Matter

  • Cincinnati is 41-33 at home this season while Pittsburgh is just 31-43 on the road
  • The Reds have won 7 of their last 9 games against the Pirates at Great American Ball Park
  • Cincinnati has scored 4+ runs in 11 of their last 14 home games
  • Pittsburgh’s team batting average of .231 ranks 28th in MLB, while their .350 slugging percentage is 26th
  • The Reds have gone 6-2 in Nick Lodolo’s last 8 starts at home
  • Pirates are just 3-11 in their last 14 day games against teams with winning records
  • Cincinnati’s run differential (+31) contrasts sharply with Pittsburgh’s (-66)

Emilio Pagán’s Dominant Season: Anchoring Cincinnati’s Playoff Push

Emilio Pagán has transformed into one of the National League’s elite closers this season, converting 29 saves with a 2.51 ERA and 0.98 WHIP. His emergence has been crucial to Cincinnati’s playoff push, as he’s blown just two save opportunities all year. Against Pittsburgh specifically, Pagán has been nearly untouchable, allowing just one hit in 5.2 innings while striking out 7. This reliable ninth-inning presence gives the Reds a significant advantage in close games, particularly important considering 40% of Cincinnati’s games have been decided by two runs or fewer. With the Reds fighting for playoff positioning, having a lockdown closer removes much of the late-inning anxiety that plagues many contending teams.

Great American Ball Park Factor: How the Venue Influences Today’s Game

Great American Ball Park ranks among MLB’s most hitter-friendly venues, particularly for power. The park factor data shows it plays at a 1.093 for overall run scoring (5th highest) and a staggering 1.384 for home runs (1st overall). These dimensions significantly favor Cincinnati’s lineup, which has adapted their approach to capitalize on the park’s characteristics. The short porches in both right (325 feet) and left (328 feet) contribute to the home run-friendly environment. Today’s forecast calls for 75°F temperatures with 8-10 mph winds blowing out to center field, further enhancing the offensive potential. Despite both pitchers’ impressive numbers, this environment can quickly turn a pitcher’s duel into a high-scoring affair, especially considering the Pirates have surrendered the 7th most home runs in MLB this season.

Expert Prediction & Best Bets for Pirates-Reds Showdown

Primary Play: Cincinnati Reds Moneyline (-165)

The Reds have too many advantages to ignore here. Lodolo’s superior performance at home (2.87 ERA), combined with Cincinnati’s reliable bullpen and significant offensive edge makes this price worth paying. Pittsburgh’s struggles on the road (31-43) further strengthen the case. While -165 isn’t a bargain, the situational advantages for Cincinnati create sufficient value. The Reds’ playoff motivation against a Pirates team playing out the string provides additional confidence in this selection.

Strong Value Play: Over 8 Runs (-115)

Great American Ball Park’s homer-friendly dimensions and today’s outward wind conditions create an environment ripe for offense despite two capable starters. The park’s 1.384 HR factor is MLB’s highest, and Cincinnati’s home games have averaged 9.1 total runs this season. While Ashcraft and Lodolo have been effective, both teams average giving up over 4 runs per game. The under 8 has received some sharp support, but I see more value on the over given the venue’s characteristics and the favorable weather conditions.

Worth Considering: Nick Lodolo Over 6.5 Strikeouts (-115)

This prop stands out as my favorite player-focused wager. Lodolo averages 8.7 K/9 this season and faces a Pirates lineup that ranks 5th in strikeout rate against left-handed pitching (24.2%). Pittsburgh’s aggressive approach plays right into Lodolo’s strengths, as he’s recorded 7+ strikeouts in 8 of his last 11 starts. With the Pirates likely chasing from behind, expect even more aggressive swings leading to additional strikeout opportunities for the Cincinnati lefty.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Nick Lodolo Over 6.5 Strikeouts -115 ★★★★☆
Elly De La Cruz To Hit a Home Run +320 ★★★☆☆
Braxton Ashcraft Under 5.5 Strikeouts -125 ★★★☆☆
Spencer Steer Over 1.5 Total Bases +110 ★★★★☆

Final Thoughts: Reds’ Playoff Push Provides Edge

This matchup showcases two promising young pitchers, but Cincinnati’s significant advantages in lineup production, bullpen strength, and home field environment make them the clear choice. The Reds’ playoff motivation provides an intangible edge that shouldn’t be overlooked. While Ashcraft has impressed for Pittsburgh, asking a rookie to shut down a playoff-caliber lineup in one of baseball’s most hitter-friendly parks is a tall order. The total presents value as well, with Great American Ball Park’s extreme home run tendencies potentially turning even well-pitched games into over territory. I’ll back Cincinnati to handle business at home while keeping an eye on Lodolo’s strikeout count against a whiff-prone Pirates lineup.

Score Prediction: Cincinnati Reds 5, Pittsburgh Pirates 3

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