Cardinals vs Giants NFL Week 4 Picks, Odds & Prediction for Sunday

by | Last updated Sep 30, 2026 | nfl

Arizona Cardinals at New York Giants NFL Week 4 matchup graphic with total pick and analysis from Joe Jensen

Arizona Cardinals at New York Giants
Sunday, October 4, 2026
1:00 PM ET, MetLife Stadium

Arizona is a 1.5-point road favorite over the Giants with a total of 43.5. My play is the Under.

The Jameis Winston factor is the entry point here. Jaxson Dart went down with a knee injury on the Giants’ opening drive of their Week 2 loss to the Rams and will miss the rest of the regular season. Since Winston took over, the Giants have scored a total of 18 points in two games — six in a 28-6 loss in Los Angeles and 12 in a 12-7 win over Tennessee, where all 12 points came on Dominic Zvada field goals. Winston has completed just 51% of his passes, the worst mark in the league, and has thrown for 229 yards across those two games.

The numbers for the whole offense back it up. New York ranks 28th in the NFL in scoring at 15.3 points per game, 29th in total offense at 271.3 yards per game and 31st in passing at 153 yards per game. That 15.3 figure is inflated by Week 1, when Dart was healthy and the Giants put up 28 in a win over Dallas. With Winston under center, this is an offense that settles for field goals, and John Harbaugh’s staff is still working newly acquired J.J. McCarthy into the playbook as the backup. Realistic Giants output: 13-17 points.

Arizona’s defense has been beatable — it has allowed 81 points through three games, including 36 in a Week 3 loss to San Francisco — but the Giants aren’t built to take advantage of it. An offense that can’t complete half its throws and hasn’t found the end zone consistently doesn’t suddenly become the unit that exploits a leaky secondary.

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The Cardinals’ offense has been up and down. They beat the Chargers 26-14 on the road in Week 1, managed just 7 points in a 31-7 home loss to Seattle in Week 2, and then put up 30 in the 36-30 loss to San Francisco. That averages out to 21 points per game, 18th in the league. Jacoby Brissett has been efficient (70.1% completions, 4 TDs, 1 INT), but the Arizona running game ranks 26th, and Brissett’s numbers fall off a cliff under pressure — a 107.4 passer rating when kept clean versus 48.9 when pressured.

That pressure split matters against the Giants. New York’s defense has been the steadiest part of this team, allowing 18.3 points per game (9th in the NFL) with five takeaways. Losing Brian Burns to a torn ACL hurts, but Abdul Carter and Kayvon Thibodeaux are still coming off the edges, and the Giants just held Tennessee to seven points. Realistic Cardinals output: 20-24 points.

Combined output range: 33-41 points. That sits under 43.5.

The Giants’ recent game script supports it too. Their last two games produced 34 and 19 total points. With Winston at quarterback, New York plays low-possession, field-goal football, and that tends to drag the total down no matter who is on the other side. The total opened at 44.5 and has slipped to 43.5 at several books, which is a small move in the same direction.

Realistic outcomes: Cardinals 21, Giants 17 (38 total); Cardinals 20, Giants 13 (33 total); Giants 19, Cardinals 17 (36 total); or Cardinals 27, Giants 20 (47 total, over). Three of four scenarios stay under 43.5. The Over needs Winston to find a rhythm he hasn’t shown yet, and the Giants’ defense to give up points it hasn’t been allowing.

The Pick: Cardinals/Giants Under 43.5

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