Brewers vs Cubs Prediction & Best Bets | Misiorowski Looks to Bounce Back in Pivotal NL Central Showdown

by | Aug 20, 2025 | mlb

Brewers vs Cubs Prediction & Best Bets | Misiorowski Looks to Bounce Back in Pivotal NL Central Showdown

The Milwaukee Brewers (79-47) aim to rebound after dropping both games of Tuesday’s doubleheader as they face the Chicago Cubs (72-54) in Wednesday’s crucial NL Central battle at Wrigley Field. I’m particularly intrigued by this pitching matchup featuring Milwaukee’s electric rookie Jacob Misiorowski against the steady veteran Colin Rea. After watching the Cubs sweep yesterday’s twin bill, Milwaukee finds themselves in a rare position of needing to stop the bleeding against a Cubs team that’s suddenly found new life in the division race. With the young fireballer Misiorowski looking to bounce back from a rough outing, this matchup presents several compelling betting angles worth targeting.

Quick Picks:

  • Best Bet: Milwaukee Brewers ML (-116) ★★★★☆
  • Top Prop: Jacob Misiorowski Over 6.5 Strikeouts (+125) ★★★☆☆
  • Value Play: Under 6.5 Runs (+108) ★★★★☆
  • Save money by betting on games at reduced odds! Every dollar matters!

Milwaukee Brewers vs Chicago Cubs Betting Odds & Latest Line Movement

Market Milwaukee Brewers Chicago Cubs
Moneyline -116 -104
Run Line -1.5 (+165) +1.5 (-195)
Total Over 6.5 (-132) Under 6.5 (+108)

Opening Line: Brewers -110, Total 7.0

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

The line movement in this matchup tells an interesting story. Despite Milwaukee dropping both games of yesterday’s doubleheader, we’ve seen the Brewers’ price strengthen from -110 to -116, indicating professional money is backing the division leaders to bounce back. Even more telling is the total dropping from 7.0 to 6.5 while the over juice has increased significantly to -132. This suggests sharp bettors are anticipating a lower-scoring affair than the market initially expected, potentially seeing value in Misiorowski’s bounce-back potential against a pitcher-friendly Wrigley Field backdrop that ranks 25th in runs scored factor (0.898).

Pitching Matchup: Jacob Misiorowski vs Colin Rea – Who Has the Edge?

Milwaukee Brewers: Jacob Misiorowski (4-1, 3.89 ERA)

  • Electric young arm coming off his worst MLB start (5 ER in 1.2 IP vs Cincinnati)
  • Impressive 50 strikeouts in just 34.2 innings (13.0 K/9 rate)
  • Recently activated from IL (left tibia contusion) on August 15
  • Four-seam fastball consistently hitting 98-100 mph with devastating slider

Chicago Cubs: Colin Rea (9-5, 3.99 ERA)

  • Former Brewer has been remarkably consistent with 3.68 ERA over his last seven starts
  • Excellent control with just 33 walks in 121.2 innings this season
  • Allowed just 1 ER on 3 hits against Pittsburgh in his last outing
  • Trending upward with quality starts in three of his last four appearances

Advantage: Slight edge to Misiorowski. Though Rea brings consistency, Misiorowski’s elite strikeout potential gives Milwaukee a higher ceiling in this matchup. His last start can be attributed to rust following his IL stint, and I expect a significant bounce-back performance from the talented rookie who dominated before his injury.

Bullpen Breakdown

Milwaukee’s bullpen remains one of baseball’s elite units despite recent usage concerns. Closer Trevor Megill (29 saves) anchors a relief corps that features high-leverage weapons in Abner Uribe (league-leading 33 holds) and Jared Koenig (23 holds). The Cubs’ bullpen is more of a committee approach with Daniel Palencia (17 saves) handling most closing duties, while Brad Keller and Caleb Thielbar have been reliable setup options. What stands out is Milwaukee’s superior bullpen depth, which becomes crucial in a tight division battle. The Brewers’ relievers have been heavily taxed during their recent 14-game winning streak, but their depth should prove advantageous in what projects to be a close, low-scoring affair at Wrigley Field.

Key Betting Trends & Team Statistics That Matter

  • Milwaukee is an impressive 42-18 when favored by -116 or more this season
  • The Cubs are 13-17 as a moneyline underdog of -102 or longer
  • Milwaukee is 7-1 ATS in Misiorowski’s eight starts this season
  • The Cubs swept Tuesday’s doubleheader, winning 6-4 and 4-1
  • Milwaukee’s offense leads the NL Central, averaging 5.16 runs per game
  • Cubs rookie Owen Caissie homered in his first start Tuesday after Kyle Tucker’s benching
  • The Brewers are 4-6 in their last 10 games at Wrigley Field
  • Seven of the last nine meetings between these teams have gone under the total

Caissie’s Coming Out Party: Can the Cubs’ Rookie Continue His Momentum?

Chicago’s decision to bench struggling star Kyle Tucker has opened the door for top prospect Owen Caissie, who made an immediate impact with his first MLB homer in Tuesday’s doubleheader opener. The 23-year-old slugger profiles as a significant power threat from the left side, but faces a challenging matchup against Misiorowski’s electric arsenal. While Caissie’s early success is promising for the Cubs’ future, I’m skeptical about his ability to maintain that production against Milwaukee’s fireballing rookie. Misiorowski’s combination of 100 mph heat and a wipeout slider presents a difficult challenge for any young hitter, especially one with limited major league experience. This individual matchup could prove pivotal in tonight’s outcome.

Wrigley Field Factor: How the Venue Influences Today’s Game

Wrigley Field has played surprisingly pitcher-friendly this season, ranking 25th in MLB with a 0.898 runs factor and 0.883 HR factor. Tonight’s forecast calls for temperatures in the mid-70s with winds blowing in from right field at 5-7 mph – conditions that further benefit pitchers. The venue’s suppression of offense plays perfectly into my handicap of a lower-scoring game. Misiorowski’s high-velocity arsenal should play up in these conditions, while Rea’s pitch-to-contact approach benefits from Wrigley’s expanded dimensions when the wind isn’t howling out. The Cubs’ recent offensive improvement notwithstanding, this environment heavily favors a pitching-dominant game.

Expert Prediction & Best Bets for Brewers-Cubs Showdown

Primary Play: Milwaukee Brewers Moneyline (-116)

I’m backing the Brewers to bounce back after yesterday’s doubleheader sweep. Milwaukee is still the superior team over the full season, and they’ve gone an impressive 42-18 as favorites of -116 or greater. Misiorowski’s elite stuff gives them significant upside in this matchup, and I expect him to perform much better than his last outing when he was clearly rusty following his IL stint. The Brewers’ bullpen depth provides a critical late-game advantage, and their offense still ranks among the NL’s best despite recent struggles. At this modest price, Milwaukee offers solid value as they look to reassert their dominance in the division race.

Strong Value Play: Under 6.5 Runs (+108)

This is my favorite bet on the board. Wrigley Field’s pitcher-friendly tendencies (0.898 runs factor) combined with winds blowing in creates ideal conditions for a low-scoring affair. Both starters have shown the ability to dominate when on their game, and I expect a motivated Misiorowski to deliver a bounce-back performance while Rea continues his steady approach. The under has hit in seven of the last nine meetings between these teams, and getting plus-money on the under 6.5 offers tremendous value in what projects to be a tense divisional battle.

Worth Considering: Jacob Misiorowski Over 6.5 Strikeouts (+125)

Despite his rough outing last time, Misiorowski’s strikeout upside remains elite. He’s averaging 13.0 K/9 this season, and the Cubs have shown vulnerability to high-velocity arms. Coming off his worst start of the season, I expect the talented rookie to refocus on his strengths – a blazing fastball and devastating slider that generate whiffs at an impressive rate. The plus-money price on this prop reflects recent struggles, but undervalues his raw strikeout potential against a Cubs lineup that will likely feature several inexperienced hitters.

THE BEST SPORTSBOOK FOR BETTING MLB PROPS IS BOVADA SPORTSBOOK! 50% SIGNUP BONUS UP TO $250 AND 75% UP TO $750 IF YOU DEPOSIT USING BITCOIN! LOW ROLLOVERS TOO! CLICK HERE TO SIGNUP NOW!

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Jacob Misiorowski Over 6.5 Strikeouts +125 ★★★☆☆
Colin Rea Under 5.5 Strikeouts -130 ★★★★☆
Christian Yelich To Hit a Home Run +410 ★★☆☆☆
William Contreras Over 1.5 Total Bases +105 ★★★☆☆
Owen Caissie Under 0.5 Hits +150 ★★★★☆

Final Thoughts: Expect Milwaukee’s Talent to Prevail in Low-Scoring Battle

After watching yesterday’s games, it’s clear the Cubs have found new life with Jameson Taillon’s return and Owen Caissie’s emergence. However, I still believe Milwaukee holds the talent edge in this matchup. Misiorowski is primed for a bounce-back performance, and the Brewers’ veteran lineup should adjust to what they saw yesterday. The key factor is Wrigley Field’s pitcher-friendly tendencies combined with favorable weather conditions, which set up perfectly for a tense, low-scoring divisional battle. Look for Milwaukee to reassert their dominance while the total stays under in a game dominated by strong pitching performances.

Score Prediction: Milwaukee Brewers 3, Chicago Cubs 2

100% Free Play up to $1,000 (Crypto Only)

BONUS CODE: PREDICTEM

BetOnline

MLB Betting Guide

New to betting on baseball? We’ve got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!