Cincinnati Reds vs Washington Nationals Pick & Best Bets – July 21

by | Jul 21, 2025 | mlb

Reds vs Nationals Prediction & Best Bets | Singer vs Irvin Pitching Duel Takes Center Stage

The Cincinnati Reds (52-48) head to the nation’s capital for a three-game series against the Washington Nationals (39-60) in a matchup that presents intriguing betting value. Both teams are coming off very different weekend series, with the Reds taking two of three from the Mets while the Nationals dropped their series to the Padres. With the Reds just 1.5 games out of the NL Wild Card race, this is a critical road series as they look to capitalize on a struggling Nationals squad. After analyzing the pitching matchup, recent form, and key trends, I’ve identified several strong betting opportunities for Monday’s opener.

Quick Picks:

  • Best Bet: Reds Moneyline (-134) ★★★★☆
  • Top Prop: Elly De La Cruz Over 1.5 Total Bases (+110) ★★★★☆
  • Value Play: First 5 Innings Under 4.5 (+105) ★★★☆☆

Cincinnati Reds vs Washington Nationals Betting Odds & Latest Line Movement

Market Cincinnati Reds Washington Nationals
Moneyline -134 +114
Run Line -1.5 (+128) +1.5 (-154)
Total Over 9 (-100) Under 9 (-122)

Opening Line: Reds -130, Total 9 (Find the absolute best MLB odds at BetAnySports Sportsbook!

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

The line movement has been minimal since opening, with the Reds shifting slightly from -130 to -134, indicating steady support but not overwhelming action. What’s caught my attention is the total, where despite Nationals Park being the 11th most hitter-friendly venue for runs (1.011 park factor), there’s been some under money as evidenced by the juice shifting to -122. Professional bettors appear to respect both starting pitchers more than their season-long numbers might suggest, particularly with Singer’s recent form improvement.

Pitching Matchup: Brady Singer vs Jake Irvin – Who Has the Edge?

Cincinnati Reds: Brady Singer (7-7, 4.32 ERA)

  • Singer has been much better than his surface stats indicate, with a 3.58 ERA over his last 7 starts
  • Excellent K/BB ratio with 92 strikeouts to just 40 walks in 100 innings pitched
  • His sinker/slider combination has been particularly effective against right-handed hitters
  • Has allowed 3 or fewer runs in 8 of his last 10 starts

Washington Nationals: Jake Irvin (7-5, 4.58 ERA)

  • Irvin has been the definition of inconsistent with a 5.72 ERA in his last 8 starts
  • Home/road splits are concerning, with a 5.22 ERA at Nationals Park this season
  • Has struggled with command, issuing 38 walks in 116 innings
  • Allowing a concerning .271 batting average to left-handed hitters

Advantage: Cincinnati Reds. Singer’s recent form and superior command give him a clear edge over Irvin, who has struggled with consistency, particularly at home.

Bullpen Breakdown

The Reds’ bullpen has been a strength this season, with closer Emilio Pagán converting 21 saves and Tony Santillan establishing himself as one of the league’s best setup men with 20 holds. Washington’s relievers have been overworked lately, throwing 16.2 innings in their weekend series against the Padres. Kyle Finnegan has been solid as their closer with 19 saves, but the bridge to get to him has been problematic. The Nationals’ bullpen sports a 4.87 ERA in July, compared to Cincinnati’s much more respectable 3.73 mark. This gives the Reds a significant advantage in the later innings.

Key Betting Trends & Team Statistics That Matter

  • The Reds are 6-4 in their last 10 games and have won 4 of their last 5 road contests
  • Cincinnati is 42-19 when recording 8+ hits in a game this season
  • Washington has lost 10 of their last 12 games overall
  • The Nationals are just 19-30 at home this season (38.8% win percentage)
  • Cincinnati has gone 24-26 on the road, making them a more respectable road team than Washington is a home team
  • The Reds have outscored opponents by 38 runs this season, while the Nationals have been outscored by 105 runs

Elly De La Cruz: Emerging Superstar Poised to Feast on Nationals’ Pitching

Elly De La Cruz has been on a tear, posting a 151 wRC+ since June 6 and establishing himself as one of the most dangerous players in baseball. With 18 doubles, 3 triples, 18 home runs, and 65 RBIs on the season, he’s become the engine that drives Cincinnati’s offense. Irvin’s struggles against left-handed hitters make this a particularly favorable matchup for De La Cruz, who also presents a constant stolen base threat against a Nationals team that’s been vulnerable to the running game. Look for De La Cruz to be the offensive catalyst in this series opener.

Nationals Park Factor: How the Venue Influences Today’s Game

Nationals Park ranks as the 11th most hitter-friendly venue for runs (1.011 park factor) and slightly above average for home runs (1.054). The forecast calls for temperatures in the low 80s with moderate humidity and light winds blowing out to center field – conditions that typically favor hitters. However, both pitchers have shown the ability to keep the ball on the ground when at their best, which could mitigate some of the park’s hitter-friendly tendencies. The dimensions (336ft to left, 402ft to center, 335ft to right) create opportunities particularly for right-handed pull hitters against Irvin, who has surrendered 16 home runs this season.

Expert Prediction & Best Bets for Reds-Nationals Showdown

Primary Play: Cincinnati Reds Moneyline (-134)

This price offers solid value on a Reds team that’s playing significantly better baseball right now. Singer gives Cincinnati an edge in the starting pitching department, and the Reds’ bullpen is both more effective and better rested. When you factor in Washington’s dismal 2-8 record in their last 10 games and the clear talent disparity between these two clubs, laying -134 with the road favorite becomes an easy decision. The Reds’ superior run differential (+38 vs -105) further supports this play.

Strong Value Play: Elly De La Cruz Over 1.5 Total Bases (+110)

De La Cruz has been the Reds’ offensive catalyst and Irvin’s struggles against left-handed hitters create a perfect storm for Cincinnati’s dynamic shortstop. He’s collected multiple total bases in 7 of his last 10 games, and his combination of power and speed makes this prop particularly appealing at plus money. With Irvin allowing a .271 average to lefties, look for De La Cruz to deliver at least one extra-base hit in this matchup.

Worth Considering: First 5 Innings Under 4.5 (+105)

Despite Nationals Park’s hitter-friendly tendencies, both starting pitchers have shown the ability to keep games under control in the early innings. Singer has allowed 3 or fewer runs in 8 of his last 10 starts, while Irvin typically struggles later in games as his pitch count rises. At plus money, the F5 under offers nice value and allows us to isolate the starting pitching matchup while avoiding potentially shaky bullpen work later in the game.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Elly De La Cruz Over 1.5 Total Bases +110 ★★★★☆
Brady Singer Over 5.5 Strikeouts -115 ★★★★☆
James Wood To Hit a Home Run +350 ★★★☆☆
TJ Friedl Over 0.5 Runs Scored -125 ★★★☆☆
Jake Irvin Under 4.5 Strikeouts +110 ★★★☆☆

Final Thoughts: Reds’ Playoff Push Continues Against Struggling Nationals

The Reds enter this series with legitimate playoff aspirations, sitting just 1.5 games out of the NL Wild Card race. Cincinnati’s balanced attack and superior pitching staff give them a clear advantage against a Nationals team that’s dropped 10 of their last 12 games. While Nationals Park can be conducive to offense, I expect Singer to outpitch Irvin and the Reds’ bullpen to shut the door late. The betting value lies with Cincinnati’s moneyline, De La Cruz’s total bases prop, and a first five innings under in what should be a game controlled by the visitors.

Score Prediction: Cincinnati Reds 5, Washington Nationals 3

100% Free Play up to $1,000 (Crypto Only)

BONUS CODE: PREDICTEM

BetOnline

MLB Betting Guide

New to betting on baseball? We’ve got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!