Diamondbacks vs White Sox Prediction & Best Bets | Injuries Cloud Arizona’s Potent Offense

by | Jun 24, 2025 | mlb

Pavin Smith Arizona Diamondbacks

The Arizona Diamondbacks (40-38) continue their series against the struggling Chicago White Sox (25-54) after a dominant 10-0 victory in the opener. However, the road ahead looks complicated with the loss of Corbin Carroll to a fractured wrist and injuries to key sluggers Eugenio Suárez and Josh Naylor. Despite these setbacks, Arizona has a significant pitching advantage with Ryne Nelson facing the White Sox bullpen game. Tonight’s matchup at Rate Field creates several betting opportunities as Chicago tries to snap their five-game home losing streak.

Quick Picks:

  • Best Bet: Arizona Diamondbacks -139 ★★★★☆
  • Top Prop: Ketel Marte Over 1.5 Total Bases (+105) ★★★★☆
  • Value Play: Under 9 Runs (-110) ★★★☆☆

Arizona Diamondbacks vs Chicago White Sox Betting Odds & Latest Line Movement

Market Arizona Diamondbacks Chicago White Sox
Moneyline -139 +117
Run Line -1.5 (+130) +1.5 (-150)
Total Over 9 (-110) Under 9 (-110)

Opening Line: Diamondbacks -135, Total 9

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

The line movement has been minimal on this game, shifting just slightly from Arizona -135 to -139 despite the news of Corbin Carroll’s injury. This suggests professional money isn’t overreacting to the injury news, recognizing that the White Sox struggles run deeper than any Diamondbacks’ roster issues. The total has held steady at 9 despite Arizona’s offensive firepower taking a hit, indicating sharps are weighing the Diamondbacks’ depleted lineup against Chicago’s vulnerable pitching staff led by an opener in Jordan Leasure.

Pitching Matchup: Ryne Nelson vs Jordan Leasure – Who Has the Edge?

Arizona Diamondbacks: Ryne Nelson (4-2, 3.88 ERA)

  • Has won back-to-back starts, allowing just one run in 5.2 innings his last time out against Toronto
  • Sporting an impressive 1.08 WHIP with 45 strikeouts in 55.2 innings
  • Dominates the White Sox historically with a perfect 2-0 record and microscopic 0.84 ERA
  • Has allowed two earned runs or fewer in five of his last six starts

Chicago White Sox: Jordan Leasure (2-4, 4.23 ERA)

  • Making his first career start as an opener after 32 relief appearances this season
  • Carries a concerning 1.52 WHIP with 34 strikeouts and 15 walks in 27.2 innings
  • Expected to pitch 1-2 innings before turning it over to a taxed White Sox bullpen
  • Has never faced the Diamondbacks in his young career

Advantage: Significant edge to Arizona. Nelson has been remarkably consistent lately and has historically owned the White Sox. Chicago’s bullpen game approach puts them at a massive disadvantage, especially after using five relievers in Monday’s blowout loss.

Bullpen Breakdown

The Diamondbacks bullpen is in excellent shape after Eduardo Rodriguez and Anthony DeSclafani handled all nine innings of Monday’s shutout victory. This gives Arizona manager Torey Lovullo plenty of fresh arms to deploy if needed. Meanwhile, Chicago’s bullpen continues to be overworked, ranking in the bottom five of MLB with a collective 4.95 ERA. The White Sox relief corps had to cover seven innings in Monday’s loss, with Dan Altavilla, Wikelman González, and Michael Kopech all throwing 25+ pitches. This significant disparity in bullpen rest and effectiveness heavily favors Arizona, even with a position player (Vinny Capra) having to pitch the ninth inning of the opener.

Key Betting Trends & Team Statistics That Matter

  • Arizona has dominated this matchup historically, winning 18 of 25 all-time meetings against Chicago
  • The Diamondbacks have won 10 of their last 13 games played at Rate Field
  • Chicago has lost five consecutive home games and is just 16-22 at Rate Field this season
  • The White Sox are 2-8 in their last 10 games and have been outscored by 25 runs during that span
  • Arizona’s 40-38 record includes a respectable 20-20 mark on the road
  • The White Sox have the third-worst team batting average (.201) over their last 10 games
  • Arizona is 27-7 when scoring at least 4 runs this season

Ketel Marte’s Hot Streak: Can the All-Star Second Baseman Keep Rolling?

Ketel Marte is putting together an All-Star caliber campaign, and his recent performance has been nothing short of spectacular. He’s recorded three or more hits in four consecutive starts, going 13-for-19 (.684) during this stretch with three doubles and three home runs. His season stats (.316 BA, 14 HR, 1.017 OPS) make him one of the most dangerous hitters in the National League, and he’ll be relied upon even more heavily with Carroll, Suárez, and possibly Naylor sidelined. Against a White Sox pitching staff that’s been regularly shelled, Marte should continue his hot streak even if the lineup around him is diminished.

Rate Field Factor: How the Venue Influences Today’s Game

Rate Field has played as a slight hitter’s park this season with park factors of 1.020 for runs and 1.058 for home runs. The ballpark’s dimensions (330 feet down the lines, 400 to dead center) create opportunities for power hitters, particularly when the Chicago summer heat arrives. Tonight’s forecast calls for temperatures around 75 degrees with winds blowing out to right field at 8-10 mph, which could benefit left-handed hitters. However, with Arizona missing several key offensive contributors and Nelson’s effectiveness against the White Sox, the park’s hitter-friendly tendencies might be somewhat neutralized. It’s worth noting that Eduardo Rodriguez is now 5-0 lifetime at Rate Field after Monday’s dominant performance, suggesting the venue doesn’t always play to its offensive reputation.

Expert Prediction & Best Bets for Diamondbacks-White Sox Showdown

Primary Play: Arizona Diamondbacks Moneyline (-139)

Despite the injury concerns, Arizona remains the significantly better team here. The starting pitching mismatch is glaring, with Nelson’s proven track record against the White Sox facing a bullpen game led by an opener with a 4.23 ERA. Chicago’s five-game home losing streak and 2-8 record in their last 10 games further reinforces their struggles. While the Diamondbacks’ lineup takes a hit without Carroll (and potentially Suárez and Naylor), they still have enough firepower with Marte, Pavin Smith, and others to handle the White Sox’s vulnerable pitching. I’m comfortable laying -139 with Arizona, and would play this up to -150.

Strong Value Play: Ketel Marte Over 1.5 Total Bases (+105)

Marte has been absolutely locked in at the plate, recording multiple extra-base hits in three of his last four games. He’s gone over 1.5 total bases in all four of his recent multi-hit outings, and I expect this trend to continue against a White Sox pitching staff that lacks dominant arms. With Marte batting second in the lineup, he should get at least four plate appearances, giving him multiple chances to cash this prop. The plus-money odds make this an excellent value considering his current form and the matchup.

Worth Considering: Under 9 Runs (-110)

While the White Sox pitching is suspect, their offense is equally problematic, ranking near the bottom of MLB in most offensive categories. Arizona’s lineup is compromised by injuries, and Nelson has been excellent lately, particularly against Chicago historically. The Diamondbacks should win, but it may not be another double-digit explosion like we saw Monday. A final score in the neighborhood of 5-2 or 6-3 seems most likely, keeping this under the total of 9 runs.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Ketel Marte Over 1.5 Total Bases +105 ★★★★☆
Ryne Nelson Over 4.5 Strikeouts -130 ★★★★☆
Pavin Smith To Hit a Home Run +400 ★★★☆☆
Luis Robert Jr. Under 0.5 Hits +190 ★★★☆☆
Geraldo Perdomo Over 0.5 RBIs +175 ★★★☆☆

Final Thoughts: Diamondbacks Should Overcome Injury Adversity

The wave of injuries hitting Arizona is concerning long-term, but tonight’s matchup still heavily favors the Diamondbacks. Nelson’s historical success against Chicago, combined with the White Sox’s decision to go with a bullpen game, creates a significant pitching advantage. While the Arizona lineup is depleted, Chicago’s own offensive struggles (hitting just .201 as a team over their last 10 games) should keep this game manageable. The Diamondbacks’ dominance in this matchup (18-7 all-time) is no coincidence, and I expect that trend to continue tonight. With careful management of their available hitters, Arizona should secure another victory in what might be a lower-scoring affair than Monday’s blowout.

Score Prediction: Arizona Diamondbacks 5, Chicago White Sox 2

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