Royals vs Cubs Pick & Predictions – July 21 Interleague Matchup at Wrigley

by | Jul 21, 2025 | mlb

Royals vs Cubs Prediction & Best Bets | Surging Cameron Faces Bullpen Game in Wrigley

The Kansas City Royals (48-52) head to the Windy City to face the MLB-leading Chicago Cubs (59-40) in what shapes up as a fascinating interleague matchup. Monday’s series opener features a compelling pitching contrast with the Royals’ emerging young lefty Noah Cameron squaring off against a Cubs bullpen game led by Ryan Brasier. Chicago sits atop the NL Central for good reason, but the Royals are quietly playing strong baseball lately, going 6-4 in their last 10 while showing improved pitching. This pitching matchup creates an opportunity for value as Wrigley Field tends to suppress scoring more than most parks.

Quick Picks:

  • Best Bet: Under 8 Runs (-110) ★★★★☆
  • Top Prop: Noah Cameron Over 5.5 Strikeouts (+115) ★★★★☆
  • Value Play: Royals First 5 Innings +0.5 (-120) ★★★☆☆

Kansas City Royals vs Chicago Cubs Betting Odds & Latest Line Movement

Market Kansas City Royals Chicago Cubs
Moneyline +118 -140
Run Line +1.5 (-165) -1.5 (+135)
Total Over 8 (-110) Under 8 (-110)

Opening Line: Cubs -130, Total 8.5

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

Early sharp action has favored the under in this matchup, causing the total to drop from 8.5 to 8 at most sportsbooks. While the Cubs opened as -130 favorites, we’ve seen some minor line movement toward Chicago (now -140) despite relatively balanced action on the moneyline. This suggests professional bettors see value on the Cubs in a pitching matchup that initially appears more favorable for Kansas City. The most notable sharp movement is on the total, however, with respected money believing Cameron’s quality and Wrigley Field’s pitcher-friendly conditions will keep scoring in check.

Pitching Matchup: Noah Cameron vs Ryan Brasier – Who Has the Edge?

Kansas City Royals: Noah Cameron (3-4, 2.31 ERA)

  • Has been a revelation for Kansas City with a sparkling 2.31 ERA across 70 innings
  • Outstanding 1.00 WHIP shows excellent command and ability to limit baserunners
  • 58 Ks in 70 innings (7.5 K/9) with only 22 walks demonstrates solid control
  • Has allowed 2 or fewer earned runs in 8 of his last 10 starts
  • Left-handed pitchers have historically performed well at Wrigley Field

Chicago Cubs: Ryan Brasier (0-0, 1.04 ERA)

  • Serving as opener in what will be a bullpen game for Chicago
  • Exceptional 0.92 WHIP and 14 Ks in 17.1 innings as a reliever
  • Likely to pitch only 1-2 innings before turning it over to the Cubs’ bullpen
  • Has not thrown more than 25 pitches in any outing this season
  • Cubs will need 5-6 relievers to cover the full game

Advantage: Kansas City. Cameron gives the Royals a significant edge in the starting pitching department. While Brasier has been excellent in short stints, the Cubs will be piecing together a full game with their bullpen, which creates uncertainty and potential vulnerability.

Bullpen Breakdown

The Cubs’ bullpen has been a major factor in their success this season, posting a collective 3.60 ERA (8th in MLB). However, Sunday’s 6-1 loss to Boston saw them use four relievers, including key arms Ryan Pressly, Drew Pomeranz, and Ethan Roberts. The Royals counter with a bullpen that’s been surprisingly effective lately, anchored by closer Carlos Estevez (26 saves). Though Estevez had to close out Sunday’s win against Miami, the majority of Kansas City’s high-leverage relievers should be available. While Chicago’s overall bullpen might be deeper, the fact they’re handling a full game creates an advantage for Kansas City, who can deploy their relievers in more traditional roles behind Cameron’s start.

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Key Betting Trends & Team Statistics That Matter

  • The Cubs are an MLB-best 32-17 at home this season, making Wrigley Field one of baseball’s toughest venues
  • Kansas City is a respectable 24-26 on the road in 2025, showing they’re not intimidated by hostile environments
  • The Royals are 6-4 in their last 10 games with a team ERA of 3.23 during that stretch
  • Chicago has scored the second-most home runs in MLB (148), averaging 1.5 per game
  • Wrigley Field ranks 25th among MLB parks in run-scoring environment (0.898 factor)
  • The Royals have allowed the 3rd fewest HRs in the American League (100) this season
  • Chicago is 6-4 in their last 10 games with a 3.52 ERA during that span
  • The teams are meeting for the first time in 2025

Seiya Suzuki’s Power Surge: Cubs’ Slugger Finding His Groove

Chicago’s outfielder Seiya Suzuki has emerged as the Cubs’ most dangerous power threat, leading the team with 26 home runs while posting a .545 slugging percentage. His recent production has been particularly impressive, and his right-handed power bat presents a challenge for the left-handed Cameron. However, Cameron has shown the ability to neutralize power hitters this season by keeping the ball down in the zone and inducing ground balls. If the Royals starter can navigate Suzuki’s at-bats carefully, it would significantly improve Kansas City’s chances of keeping this game close. The matchup represents a classic power-versus-command dynamic that could determine the outcome.

Wrigley Field Factor: How the Venue Influences Today’s Game

Wrigley Field has played surprisingly pitcher-friendly in 2025, ranking 25th among MLB parks in run-scoring with a 0.898 factor. The ballpark’s home run suppression (0.883 factor) is particularly relevant given Chicago’s reliance on the long ball. Monday’s forecast calls for temperatures around 75 degrees with winds blowing in from left field at 8-10 mph, creating conditions that should further benefit pitchers. The Cubs have adapted well to their home park, but tonight’s conditions combined with Cameron’s ground-ball tendencies could create a lower-scoring environment than the betting market initially anticipated. Wrigley’s reputation as a hitter’s park often creates value on unders in the right conditions, and tonight appears to present such an opportunity.

Expert Prediction & Best Bets for Royals-Cubs Showdown

Primary Play: Under 8 Runs (-110)

I’m making the under my primary play in this matchup based on several compelling factors. First, Noah Cameron has been consistently excellent with a 2.31 ERA and 1.00 WHIP. Second, Wrigley Field is playing as a pitcher’s park this season (0.898 run factor). Third, Monday’s forecast calls for winds blowing in, further suppressing offense. While the Cubs have power throughout their lineup, Cameron’s ability to keep the ball on the ground should neutralize their home run potential. Even with Chicago using a bullpen game, their relievers have been effective enough to keep this a relatively low-scoring affair. Both teams have shown strong pitching lately with ERAs under 3.60 in their last 10 games. I’d play this under down to 7.5.

Strong Value Play: Royals First 5 Innings +0.5 (-120)

With the significant starting pitching advantage belonging to Kansas City, I see substantial value in backing the Royals for the first half of the game. Cameron’s consistency gives Kansas City a strong chance to be leading or tied through five innings against Chicago’s bullpen approach. The Cubs will be mixing and matching relievers early, creating potential vulnerabilities that the Royals can exploit. Kansas City has been competitive early in games during their recent 6-4 stretch, and Cameron has allowed two or fewer runs in the majority of his starts. At -120, the Royals to be ahead or tied after five innings offers solid value.

Worth Considering: Noah Cameron Over 5.5 Strikeouts (+115)

Cameron’s strikeout numbers don’t jump off the page at first glance (58 Ks in 70 innings), but this matchup sets up well for him to exceed his usual total. The Cubs rank among the top 10 in strikeout rate against left-handed pitching this season, and Cameron’s breaking pitches should be effective in the friendly Wrigley conditions. In his last three starts against aggressive lineups, Cameron has recorded 6, 6, and 7 strikeouts. At plus-money odds, there’s significant value on the young lefty surpassing this reasonable strikeout total, especially if he can work efficiently and complete 6+ innings.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Noah Cameron Over 5.5 Strikeouts +115 ★★★★☆
Bobby Witt Jr. Over 1.5 Total Bases +105 ★★★★☆
Seiya Suzuki Under 1.5 Total Bases +120 ★★★☆☆
Salvador Perez To Hit Home Run +425 ★★★☆☆

Final Thoughts: Pitching Edge Creates Value Opportunity

This interleague matchup presents a fascinating contrast between the MLB-leading Cubs and a Royals team that’s playing better than their record indicates. While Chicago rightfully deserves favorite status at home, the pitching matchup creates several value opportunities. Noah Cameron’s excellent 2.31 ERA gives Kansas City a substantial edge over Chicago’s bullpen game approach. Combined with Wrigley Field’s pitcher-friendly conditions and winds blowing in, we have a recipe for under 8 runs. The Royals should keep this game competitive throughout, especially early behind Cameron’s solid performance. The Cubs may still prevail with their superior lineup and home-field advantage, but expect a tighter, lower-scoring affair than the betting market suggests.

Score Prediction: Chicago Cubs 4, Kansas City Royals 3

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