Reds vs Cubs Prediction & Best Bets | Pitching Duel Brewing at Wrigley Field

by | Aug 5, 2025 | mlb

Reds vs Cubs Prediction & Best Bets | Pitching Duel Brewing at Wrigley Field

The Cincinnati Reds (59-54) visit the Chicago Cubs (65-47) Tuesday night at Wrigley Field, where a compelling pitching matchup awaits between trade deadline acquisition Zack Littell and Cubs standout Shota Imanaga. After claiming the series opener 3-2 behind an impressive bullpen performance, Cincinnati looks to continue their momentum against a Cubs team that’s suddenly facing rotation uncertainty following Michael Soroka’s shoulder injury in his debut. With both teams fighting for playoff positioning in the tight NL wild card race, expect a strategic battle between two well-matched clubs.

Quick Picks:

  • Best Bet: Under 8 Runs (-110) ★★★★☆
  • Top Prop: Elly De La Cruz Over 1.5 Total Bases (+130) ★★★★☆
  • Value Play: Reds Run Line +1.5 (-125) ★★★★★

Cincinnati Reds vs Chicago Cubs Betting Odds & Latest Line Movement

Market Cincinnati Reds Chicago Cubs
Moneyline +153 -185
Run Line +1.5 (-125) -1.5 (+105)
Total Over 8 (-110) Under 8 (-110)

Opening Line: Cubs -175, Total 8

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

The early money movement in this matchup has been subtle but telling. The line opened with Chicago as a -175 favorite and has ticked up slightly to -185, suggesting some professional money is backing the home team despite Cincinnati’s series-opening victory. However, I’m more interested in what hasn’t moved—the total has remained steady at 8 despite two quality starting pitchers taking the mound in a venue that suppresses scoring (0.898 run factor, 25th in MLB). This lack of movement toward the under indicates sharp resistance, with professional bettors likely respecting both offenses despite the pitching matchup.

Pitching Matchup: Zack Littell vs Shota Imanaga – Who Has the Edge?

Cincinnati Reds: Zack Littell (8-8, 3.58 ERA)

  • Making his Reds debut after being acquired from Tampa Bay at the trade deadline
  • Excellent command with just 21 walks in 133.1 innings pitched (1.42 BB/9)
  • Pitched to a 3.16 ERA in July with opponents hitting just .224 against him
  • Solid 1.12 WHIP demonstrates his ability to limit baserunners

Chicago Cubs: Shota Imanaga (8-4, 3.25 ERA)

  • The Japanese lefty has been a consistent bright spot in the Cubs rotation
  • Elite control with just 17 walks in 83 innings pitched (1.84 BB/9)
  • Superb 1.04 WHIP shows his effectiveness at keeping runners off base
  • Has been especially effective at Wrigley Field with a 2.88 home ERA

Advantage: Slight edge to Chicago. While both pitchers feature excellent command and similar effectiveness, Imanaga’s familiarity with his team and dominance at home gives him a narrow advantage. Littell’s first start with a new club introduces an element of uncertainty despite his strong overall numbers.

Bullpen Breakdown

Cincinnati’s bullpen has been taxed heavily over the past three days. Monday’s unplanned bullpen game following Nick Lodolo’s early exit (blister) forced key relievers Scott Barlow (2 IP) and Emilio Pagán into action. This came on the heels of another bullpen-heavy game in the rain-delayed Speedway Classic fiasco over the weekend. The Reds bullpen has been surprisingly resilient, however, with Pagán converting 24 saves (7th in MLB) and Tony Santillan establishing himself as an elite setup man with 24 holds (3rd in MLB).

Chicago’s relief corps features a more distributed workload with Daniel Palencia (15 saves) leading a group that includes Brad Keller (17 holds) and Caleb Thielbar (14 holds). The Cubs’ bullpen depth should prove advantageous tonight given the Reds’ recent heavy usage patterns, though Cincinnati has shown remarkable adaptability in high-leverage situations.

Key Betting Trends & Team Statistics That Matter

  • Cubs are 35-21 at Wrigley Field this season, one of the best home records in the National League
  • Reds are 26-28 on the road but have won 6 of their last 10 games overall
  • Chicago has taken 4 of 7 meetings between these teams this season
  • Cubs are just 5-5 in their last 10 games despite their strong overall record
  • Cincinnati’s team OPS of .711 ranks 14th in MLB while Chicago’s .763 puts them in the top 8
  • The Reds have outscored opponents by a modest +43 run differential; Cubs boast a +114 differential
  • Wrigley Field’s park factor of 0.898 for runs ranks 25th in MLB, making it pitcher-friendly

Elly De La Cruz Spotlight: Dynamic Shortstop Finding Consistency

Elly De La Cruz has shown continued maturation as a hitter over the past month, delivering an RBI double in Monday’s victory. The electrifying shortstop has reduced his strikeout rate since the All-Star break while maintaining his power and speed combination that makes him one of baseball’s most dynamic talents. Against left-handed pitching like Imanaga, De La Cruz has shown improved discipline, posting a .278 average with a .502 slugging percentage versus southpaws this season. His approach will be tested against Imanaga’s pinpoint control, creating one of the game’s most intriguing batter-pitcher matchups.

Wrigley Field Factor: How the Venue Influences Today’s Game

Wrigley Field has played as one of baseball’s more pitcher-friendly venues this season with a 0.898 run factor (25th in MLB) and 0.883 home run factor (26th). The famous wind patterns make game-day conditions crucial to handicapping, and tonight’s forecast calls for winds blowing in from right field at 8-10 mph with comfortable temperatures in the mid-70s. These conditions further enhance the pitching advantage, particularly for Imanaga who has mastered the art of using Wrigley’s dimensions to his advantage. The Cubs’ home park has helped them compile their impressive 35-21 home record, though Cincinnati’s pitching staff has performed well in similar environments this season.

Expert Prediction & Best Bets for Reds-Cubs Showdown

Primary Play: Under 8 Runs (-110)

I’m confidently backing the under in this matchup. With two command specialists on the mound, Wrigley’s run-suppressing tendencies, and winds blowing in, runs should be at a premium. Both Littell (1.12 WHIP) and Imanaga (1.04 WHIP) excel at limiting baserunners, and neither offense has been particularly explosive lately. The Cubs have scored just 2 runs in three of their last five games, while the Reds have topped 4 runs just twice in their last six contests. I see this finishing around 3-2 either way.

Strong Value Play: Reds Run Line +1.5 (-125)

The run line offers excellent value in what projects to be a tight, low-scoring affair. Cincinnati has proven resilient despite their challenging schedule and travel circumstances, winning Monday’s opener despite losing their starter in the second inning. Littell’s command and ability to work deep into games (averaging over 6 innings per start) should keep the Reds competitive throughout. With five of the seven meetings between these teams this season decided by 2 runs or fewer, the +1.5 at reasonable juice presents strong value.

Worth Considering: Elly De La Cruz Over 1.5 Total Bases (+130)

De La Cruz has been heating up and has shown significant improvement against left-handed pitching. His combination of power and speed means he can clear this threshold with one well-hit ball, and he’s been more disciplined at the plate recently. While Imanaga is excellent, De La Cruz’s ability to turn any mistake into extra bases makes this prop appealing at plus-money odds. The young star has exceeded 1.5 total bases in 6 of his last 10 games.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Elly De La Cruz Over 1.5 Total Bases +130 ★★★★☆
Shota Imanaga Over 5.5 Strikeouts -120 ★★★★☆
Zack Littell Under 2.5 Walks -140 ★★★★★
Spencer Steer To Record an RBI +175 ★★★☆☆
Seiya Suzuki Over 1.5 Total Bases +125 ★★★☆☆

Final Thoughts: Pitching Prowess Will Prevail at Wrigley

This matchup has all the ingredients of a tight, well-pitched ballgame where execution in key moments will determine the outcome. The Cubs remain rightful favorites at home with Imanaga on the mound, but Littell’s command and the Reds’ resilience make them dangerous underdogs. I expect pitching to dominate the narrative in a game where runs will be at a premium. The smart play is backing the under and taking the Reds with the run line cushion, as we’re likely to see a close contest that could come down to bullpen management and timely hitting in the late innings.

Score Prediction: Cubs 3, Reds 2

100% Free Play up to $1,000 (Crypto Only)

BONUS CODE: PREDICTEM

BetOnline

MLB Betting Guide

New to betting on baseball? We’ve got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!