Cincinnati Reds vs St. Louis Cardinals Pick & Odds for Sept 17

by | Sep 16, 2025 | mlb

Reds vs Cardinals Prediction & Best Bets | Abbott's Dominance Key in NL Central Showdown

The Cincinnati Reds (75-75) head to Busch Stadium for a pivotal NL Central matchup against the St. Louis Cardinals (73-78) on Tuesday night. With the Reds coming off an impressive 11-6 victory in the series opener, they’re looking to build momentum behind ace Andrew Abbott, who has been one of the most consistent starters in the National League this season. This pitching matchup heavily favors Cincinnati, as Abbott’s elite 2.79 ERA provides a significant edge over the Cardinals’ Michael McGreevy, who has struggled with consistency in his rotation role.

Quick Picks:

  • Best Bet: Cincinnati Reds Moneyline (-113) ★★★★☆
  • Top Prop: Andrew Abbott Over 5.5 Strikeouts (-115) ★★★★☆
  • Value Play: Cincinnati Reds -1.5 (+155) ★★★☆☆

Cincinnati Reds vs St. Louis Cardinals Betting Odds & Latest Line Movement

Market Cincinnati Reds St. Louis Cardinals
Moneyline -113 -107
Run Line -1.5 (+155) +1.5 (-180)
Total Over 8.0 (-115) Under 8.0 (-105)

Opening Line: Reds -112, Total 8.5

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

While the public has been moderately backing the Reds following their offensive explosion in Monday’s 11-6 win, sharp money has been relatively split on this matchup. The overnight line movement has been minimal, with the Reds opening at -112 and now sitting at -113, suggesting balanced action. However, I’ve noticed professional bettors showing interest in the under, as the total has dropped slightly from 8.5 to 8 despite Abbott’s dominant pitching profile creating natural under appeal. The run line at +155 for Cincinnati also offers significant value considering Abbott’s ability to pitch deep into games with their reliable closer Emilio Pagán (27 saves) waiting in the wings.

Pitching Matchup: Andrew Abbott vs Michael McGreevy – Who Has the Edge?

Cincinnati Reds: Andrew Abbott (9-6, 2.79 ERA)

  • Abbott has been a model of consistency with a stellar 2.79 ERA across 151.2 innings
  • Excellent command with just 42 walks against 136 strikeouts (3.2 K/BB ratio)
  • Maintains a superior 1.13 WHIP, limiting hard contact consistently
  • Especially effective on the road, where he’s held opponents to a .230 batting average

St. Louis Cardinals: Michael McGreevy (6-3, 4.44 ERA)

  • McGreevy has been serviceable but unspectacular with a 4.44 ERA in 79 innings
  • Shows excellent control with only 12 walks, but lacks swing-and-miss stuff (just 47 Ks)
  • Has allowed 8 home runs in his last 6 starts, a concerning trend against Cincinnati’s power
  • Maintains a solid 1.23 WHIP but tends to pitch to contact, creating risk against better lineups

Advantage: Significant edge to Cincinnati. Abbott’s 2.79 ERA and superior strikeout ability give the Reds a major advantage in this pitching matchup. McGreevy’s contact-heavy approach is particularly concerning against a Reds lineup that just exploded for 11 runs in the series opener.

Bullpen Breakdown

The Reds hold a distinct advantage in the late innings with Emilio Pagán anchoring their bullpen with 27 saves, ranking 9th in MLB. Their setup corps is equally impressive, with Tony Santillan ranking 3rd in the league with 29 holds. The Cardinals’ bullpen has been less reliable, with JoJo Romero (7 saves) handling closing duties but lacking the consistent dominance of Cincinnati’s relief corps. St. Louis has struggled to maintain leads, which becomes particularly problematic when trailing early. With Abbott’s ability to work deep into games (averaging over 6 innings per start), the Reds can deploy their high-leverage relievers in optimal situations, giving them a significant edge if this game remains close in the late innings.

Key Betting Trends & Team Statistics That Matter

  • The Reds have dominated the recent head-to-head series, winning 6 of the last 10 meetings
  • Cincinnati has been profitable as a road favorite this season, going 12-8 (+3.6 units) in that role
  • Andrew Abbott has allowed 2 or fewer earned runs in 7 of his last 9 starts
  • The Cardinals are just 32-39 at Busch Stadium this season, negating typical home-field advantage
  • Cincinnati’s offense has been surging, averaging 5.3 runs per game over their last 10 contests
  • St. Louis ranks 24th in home runs per game (0.93) while Cincinnati ranks in the top half (1.01)
  • The Reds have a +25 run differential on the season compared to the Cardinals’ -57

Elly De La Cruz Factor: Impact Player for Tuesday’s Contest

Cincinnati’s dynamic shortstop Elly De La Cruz has been the catalyst for the Reds’ offense this season, leading the team with a .263 batting average, .333 OBP, and .435 slugging percentage. His combination of power and speed creates matchup problems for the contact-oriented McGreevy, who lacks the velocity to consistently challenge De La Cruz. In the series opener, De La Cruz reached base three times and scored twice, highlighting his game-changing ability. His presence at the top of the order forces pitchers to work from the stretch and disrupts defensive alignments, creating opportunities for the entire Cincinnati lineup. McGreevy’s pitch-to-contact approach plays directly into De La Cruz’s strengths, making him a prime candidate for a multi-hit, high-impact performance tonight.

Busch Stadium Factor: How the Venue Influences Today’s Game

Busch Stadium has traditionally played as a pitcher-friendly park, ranking 16th in run-scoring environment with a 0.992 park factor. The stadium suppresses home runs even more significantly (0.917 HR factor), which theoretically benefits both pitchers. However, this advantage disproportionately helps Abbott, who already excels at limiting hard contact. McGreevy relies heavily on his defense and keeping the ball in the park, but the Reds’ lineup features several hitters who can drive the ball to all fields. While the dimensions might contain some would-be home runs, Cincinnati’s approach of stacking baserunners and manufacturing runs plays well in this environment. The weather forecast calls for mild temperatures around 72°F with light winds, providing neutral conditions that should allow Abbott’s pitching prowess to shine through without environmental interference.

Expert Prediction & Best Bets for Reds-Cardinals Showdown

Primary Play: Cincinnati Reds Moneyline (-113)

This is my strongest play of the night. Andrew Abbott gives the Reds a significant advantage on the mound, and his 2.79 ERA stands in stark contrast to McGreevy’s 4.44 mark. Cincinnati’s offense is clicking after putting up 11 runs in the series opener, and they face a pitcher in McGreevy who allows consistent contact. The price of -113 represents excellent value given the pitching mismatch, and I’d play this up to -125 without hesitation. The Reds’ bullpen advantage with Pagán and Santillan handling late innings seals the deal here.

Strong Value Play: Cincinnati Reds -1.5 (+155)

Getting +155 on the Reds run line represents tremendous value given Abbott’s ability to limit scoring and Cincinnati’s recent offensive production. In Abbott’s starts this season, the Reds have won by multiple runs in 8 of his 9 victories, showing that when he’s on, they tend to win comfortably. McGreevy’s tendency to allow contact means the Reds should be able to string together multiple scoring innings, while Abbott’s elite ERA suppresses the Cardinals’ offense enough to create margin for a cover.

Worth Considering: Andrew Abbott Over 5.5 Strikeouts (-115)

Abbott has consistently shown the ability to miss bats, averaging nearly a strikeout per inning this season (136 Ks in 151.2 IP). The Cardinals rank middle-of-the-pack in strikeout rate, and Abbott’s deceptive delivery and plus breaking ball should generate swings and misses. He’s exceeded this strikeout total in 6 of his last 9 starts, and the controlled environment of Busch Stadium allows him to attack the zone with confidence. At near-even money, this prop offers solid value based on Abbott’s season-long performance.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Andrew Abbott Over 5.5 Strikeouts -115 ★★★★☆
Elly De La Cruz Over 1.5 Total Bases +120 ★★★★☆
TJ Friedl To Record a Hit -175 ★★★☆☆
Michael McGreevy Under 4.5 Strikeouts -140 ★★★★☆

Final Thoughts: Abbott’s Excellence Gives Reds Clear Path to Victory

When analyzing this matchup comprehensively, Andrew Abbott stands out as the difference-maker. His 2.79 ERA represents elite-level pitching, and he’s consistently delivered quality starts throughout the season. The Cardinals have struggled at home this year (32-39), and their -57 run differential highlights their overall inefficiency. Cincinnati’s recent offensive surge, coupled with their bullpen advantage featuring Pagán and Santillan, creates a perfect storm for the Reds to secure another victory. While McGreevy has shown flashes of competence, his pitch-to-contact approach is precisely what Cincinnati’s lineup feasts on. I’m confidently backing the Reds to win outright, with strong consideration for the run line at the attractive +155 price point.

Score Prediction: Cincinnati Reds 5, St. Louis Cardinals 2

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