Padres vs. Giants Odds, Analysis, Predictions 5/21/22

by | Last updated May 21, 2022 | mlb

San Diego Padres vs San Francisco Giants

Date: Saturday, May 21st, 04:05 ET

Location: Oracle Park

TV: Bally Sports San Diego

Money Line: Padres +117 / Giants -140 (Bovada – 50% bonus up to $250 and rebates on ALL your bets; even if they win!)

Total Line: 7.0


San Diego: Joe Musgrove (4-0, 2.2)
San Francisco: Carlos Rodón (4-2, 3.49)

Padres Projected Lineup

Ha-seong Kim SS
Austin Nola C
Luke Voit 1B
Wil Myers RF
Manny Machado 3B
Jose Azocar CF
Eric Hosmer 1B
Jake Cronenworth 2B
Jurickson Profar LF
Joe Musgrove P

Giants Projected Lineup

Brandon Crawford SS
Wilmer Flores 3B
Mike Yastrzemski RF
LaMonte Wade Jr LF
Evan Longoria 3B
Joey Bart C
Tommy La Stella 2B
Joc Pederson LF
Brandon Belt 1B
Carlos Rodón P


San Diego Padres: 25-14-0 SU / OU 19-20-0 / Run Line W/L 22-17-0
San Francisco Giants: 22-16-0 SU / OU 21-16-1 / Run Line W/L 18-20-0

The San Francisco Giants host the San Diego Padres on Saturday, May 21st at Oracle Park. The first pitch in this matchup is scheduled for 04:05 ET. The MLB Odds Board places San Francisco as the favorite (-140), with an OU line set at 7.0.

Recent Form

The San Diego Padres will look to add another win to their resume after pulling out a slim 8-7 win over the SF Giants. The Padres benefited from an offense that generated 8 runs on 11 hits. This victory came despite being the betting underdog, getting 110.0 on the moneyline. This games went over the posted over-under line of 7.5 runs. On the season, San Diego’s over-under record is 19-20-0.

In the Padres’ last 5 games, they are above .500, going 4-1. During this time, they have an average scoring differential 7. San Diego’s offense heads into action averaging 4.0 runs per game in their last 5 contests. Similar to their season average of 4.44. So far, San Diego has won over half of their 13 series played, going 8-3-2.

The Giants will look to bounce back from a tight 8-7 loss to the Padres. In the game, the team’s pitching staff allowed a total of 11 hits, leading to 8 runs. Offensively, they finished with 7 runs on 10 hits. San Francisco came away with a loss, despite being favored on the moneyline (-120.0). So far, the team has won 66.0% of the games in which they were favored. The Giants and Padres went over the run total line set at 7.5 runs. Overall, the team has gone over the betting line in over half of their games, going 21-16-1.

The Giants come into today’s game looking to turn things around, as they are just 2-3 over their last 5 games. This recent slump is backed by a scoring margin of -8 over their last 5 games. Their recent record comes while the offense has picked up its play, averaging 6.6 runs over their last 5 game, compared to their overall figure of 5.16. On the season, San Francisco has won more than half of their series, going 7-5-2.

Pitching Matchup

San Diego will roll with Joe Musgrove (4-0) as their starter. Currently, Musgrove has a strong ERA of just 2.2 while pitching an average of 6.43 innings per outing. In his previous outings, right-hander opponents are hitting 0.217 off the right-hander. So far, Musgrove has managed to keep the ball in the ballpark, allowing just 0.8 home runs per 9 innings. Per game, Joe Musgrove is averaging 6.71, on a strikeout percentage of 27.0%. Throughout the season, Musgrove has avoided walking batters, allowing just 1.2 per contest.

San Francisco will roll with Carlos Rodón (4-2) as their starter. To date, Rodón has an ERA of 3.49 while lasting an average of 5.46 innings per appearance. Rodón comes into the game with a batting average allowed of 0.214. Opposing batters are hitting for power at a below-average rate against Rodón, as he is allowing just 0.24 per 9 innings. In terms of strikeouts, Carlos Rodón has a strong strikeout percentage of 36.0%, including a per game average of 8.0. For the season, he has struggled with command averaging 3.03 walks per outing.

San Diego vs San Francisco History

For the season, San Diego Padres and San Francisco Giants will be playing their 4th game of the season. Today’s game will be a rubber match for the two teams, as San Diego and San Francisco each have 2 wins. Through 4th games, the series’ over-under record is 2-2, with the average run total sitting at 8.84 runs per game. The averge scoring margin in these meetings is 3.75 runs. Dating back to last season, the San Francisco picked up 11 wins compared to 8, taking the season series. In these 19 meetings, the two teams combined for an over-under record of 12-7. Last year, the Padres and Giants averaged 8.84 runs per game. On average, the winning team won by a margin of 3.47 runs per contest.More Picks: Dodgers at Phillies Pick 5/21/22 >>>

Betting Trends

  • San Diego is 6-1 ATS in its last 7 games on the road
  • San Diego is 6-1 ATS in its last 7 games
  • San Francisco is 5-1 SU in its last 6 games at home
  • The total has gone OVER in 5 of San Francisco’s last 6 games at home

San Diego Padres at San Francisco Giants Prediction

In today’s NL West showdown between the Giants and Padres, I recommend taking San Diego to pick up another win over their division rival. In his first 7 starts, Musgrove has yet to give up more than 2 runs, while going at least 6 innings in every outing. Look for the right-hander to shut down the San Francisco lineup.

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