Cardinals vs Cubs betting preview for Sept 28. Pitching matchup at Wrigley highlights value on the total, moneyline, and player props for this NL Central finale.
MLB Baseball Picks
Get the latest MLB picks, predictions, and betting analysis from Predictem’s handicappers, with coverage built around starting pitching matchups, bullpen form, advanced splits, and line value. From run line and total picks to full game breakdowns, this page brings together the most actionable MLB betting content on the board.
Our MLB Betting Tips section focuses on how to bet on MLB with proven handicapping strategy and in-depth betting education, helping bettors break down matchups, understand line movement, and build a smarter, more consistent approach to MLB wagering.
Pirates vs Braves Prediction & Best Bets | Battle of Struggling Veterans on Season’s Final Day
Struggling veteran Charlie Morton in what should be his career finale. Johan Oviedo gets the ball for the Pirates in Sunday’s season closer at Truist Park. Get Joe’s take on this game and his beer money side play.
Dodgers vs Mariners Moneyline, Total & Prop Bets (Sept 28)
Dodgers vs Mariners betting preview for Sept 28. Kershaw starts the finale against Bryce Miller. See moneyline picks, totals, and top prop bets to target.
Mets vs Marlins Prediction & Best Bets | Manaea Seeks Redemption in Miami Finale
Mets and Marlins close their 2025 season Sunday at loanDepot park with Manaea’s road woes facing Cabrera’s home success. Sharp angles on moneyline, strikeout props, and game total plays.
Jays vs Rays Betting Picks & Best Bets | Gausman Looks to Dominate
Blue Jays vs Rays betting preview for Sept 28. Division title on the line — Toronto clinches the AL East with a win. Gausman starts in Sunday’s finale.
White Sox vs Nationals Prediction & Best Bets | Clash of Rebuilding Teams Offers Value Opportunities
Rebuilding White Sox and Nationals clash Sunday at Nationals Park with Shane Smith facing Brad Lord. Key strikeout props, run scoring trends, and live dog value highlight our top plays.
Twins vs Phillies Betting Picks & Predictions (Sept 28)
Twins vs Phillies betting preview for Sept 28. Sanchez faces Woods Richardson at Citizens Bank Park with moneyline value, strikeout props, and player prop picks in focus.
Orioles vs Yankees Prediction & Best Bets | AL East Playoff Race Heats Up in the Bronx
Orioles vs Yankees betting preview for Sept 27. Bradish takes the mound against Gil in the Bronx with strikeout props, run line value, and player props in focus.
Rockies vs Giants Prediction & Best Bets | Webb Seeks Statement Win in Season Finale
Giants ace Webb faces struggling rookie Brown in Sunday’s Oracle Park finale, creating prime run line value and strikeout prop opportunities. Matt Chapman bases play highlights player props.
Royals vs Athletics Prediction & Best Bets | Wacha Takes on Promising Rookie Morales
Royals vs Athletics betting preview for Sept 27. Wacha’s veteran consistency meets Morales’ rookie upside. We break down moneyline value, totals plays, and strikeout props.
MLB Baseball Picks
Athletics vs. Giants Pick: Jump’s 2.37 ERA Meets a Compromised Mahle- Braves vs. Padres Pick: Perez’s 2.78 ERA Meets a Depleted Lineup at Petco
- Diamondbacks vs. Cardinals Pick: Liberatore’s 5.23 ERA Meets a Power Lineup
- Brewers vs. Reds Pick: Lowder’s 4.82 ERA Meets a Hitter-Friendly Park
- Astros vs. Blue Jays Pick: Burrows’ .416 xwOBA and a Total That Looks Soft
- Athletics vs. Giants Pick: Jump’s 2.37 ERA Meets a Compromised Mahle
- Braves vs. Padres Pick: Perez’s 2.78 ERA Meets a Depleted Lineup at Petco
- Diamondbacks vs. Cardinals Pick: Liberatore’s 5.23 ERA Meets a Power Lineup
- Brewers vs. Reds Pick: Lowder’s 4.82 ERA Meets a Hitter-Friendly Park
- Astros vs. Blue Jays Pick: Burrows’ .416 xwOBA and a Total That Looks Soft
MLB Betting Guide
New to betting on baseball? We've got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!