Sunday MLB kicks off with an early game between the San Francisco Giants vs. Cincinnati Reds. The weather will be perfect with a forecasted first pitch temperature of 75 degrees, which is perfect hitting conditions. Get our SF/Cin prediction here!
MLB Baseball Picks
Get the latest MLB picks, predictions, and betting analysis from Predictem’s handicappers, with coverage built around starting pitching matchups, bullpen form, advanced splits, and line value. From run line and total picks to full game breakdowns, this page brings together the most actionable MLB betting content on the board.
Our MLB Betting Tips section focuses on how to bet on MLB with proven handicapping strategy and in-depth betting education, helping bettors break down matchups, understand line movement, and build a smarter, more consistent approach to MLB wagering.
Phillies vs Mets Odds & Picks
The Phillies are 1-3 over their last four games and the Mets are 6-3 over their last nine. You can throw all the stats and records out the window though, as these teams are tough to predict when they get together!
Cubs vs White Sox Runline Pick
The “Crosstown Classic” kicks off Saturday at Guaranteed Rate Field with Keegan Thompson pitching for the Cubbies and Johnny Cueto taking the mound for the ChiSox. Read our full game preview and get our ChC/CWS prediction here!
Yankees vs Rays Best Bet 5/28/22
The New York Yankees appear to be hot again, winners of four games in a row and coming off a filthy pitching performance that saw Jameson Taillon toss eight innings while only allowing two hits and no free passes. Get our NYY/TB prediction here!
Brewers vs Cardinals Odds & Moneyline Pick
The Brewers and Cardinals square off Saturday afternoon with Adrian Houser vs. Matthew Liberatore, who doesn’t appear ready for the big leagues as evidenced by his 9 walks/hits allowed in only 4.2 innings pitched vs. a light hitting Pirates team. Get our Mil/Stl pick here!
Orioles vs Red Sox Betting Stats & Predictions
The Baltimore Orioles went ham on the Boston Red Sox yesterday, erasing a six run deficit to win by a final score of 12-8. The O’s are now 5-3 over their last eight games. Get our Saturday Bal/Bos prediction here!
Pirates vs. Padres Total Pick 5/27/22
Thirty-three year old pitcher Jose Quintana has pitched really well this season. The Pirates can’t hit and they’re not likely to start doing so against tough lefty Sean Manaea. At first glance the UNDER looks appealing here. Get our Pit/SD prediction before placing your bets!
Astros vs. Mariners Recommended Bet 5/27/22
Jason Verlander has been flat nasty this season with 6-1 record and 1.22 ERA. Ironically, Chris Flexen has a 1-6 record and has given up 14 earned runs in his last 14 innings. Are the Astros an autobet here? Get our Hou/Sea prediction here!
Today’s Free MLB Pick: Yankees vs. Rays
A Jameson Taillon vs. Jeffrey Springs matchup won’t turn many heads, but is a baseball purists dream, as both pitchers are throwing the ball really well right now. Get Dan’s NYY/TB pick here!
Phillies vs. Mets Moneyline Bet 5/27/22
Is it me, or does it feel like the Philadelphia Phillies and New York Mets play every night? Eflin and Carrasco go at it Friday night at Citi Field in a game where literally anything can happen, due to their inconsistency. Get our Phi/NYM prediction here!
MLB Baseball Picks
Rangers vs. Tigers Prediction: Leiter’s K-Rate Edge Against Contact-Heavy Holton- Royals vs. Mariners Best Bet: Command Gap in Pitcher-Friendly Environment
- White Sox vs. Padres Prediction: Kay’s 6.12 ERA Meets Canning’s Sub-4.00 Mark
- Mets vs. Angels Prediction: Holmes’ Regression Risk Meets Plus Money
- Guardians vs. Athletics Best Bet: Messick’s 1.73 ERA Meets Civale’s Contact Problems
- Rangers vs. Tigers Prediction: Leiter’s K-Rate Edge Against Contact-Heavy Holton
- Royals vs. Mariners Best Bet: Command Gap in Pitcher-Friendly Environment
- White Sox vs. Padres Prediction: Kay’s 6.12 ERA Meets Canning’s Sub-4.00 Mark
- Mets vs. Angels Prediction: Holmes’ Regression Risk Meets Plus Money
- Guardians vs. Athletics Best Bet: Messick’s 1.73 ERA Meets Civale’s Contact Problems
MLB Betting Guide
New to betting on baseball? We've got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!