NFL Football Picks

Get the latest NFL picks, predictions, and betting analysis from Predictem’s handicappers, with coverage built around matchup edges, situational spots, injury impact, and line value. From point spread and total picks to full game breakdowns, this page brings together the most actionable NFL betting content on the board.

Our NFL Betting Tips section is built around NFL betting strategy and education, giving bettors a clear framework for how to bet on football, interpret line movement, and attack the market with discipline. If you’re serious about finding value each week, keep this page in your rotation.

MNF Big Bet: Broncos at Seahawks Pick

MNF Big Bet: Broncos at Seahawks Pick

Russell Wilson playing against the Seattle Seahawks on Monday Night Football in Week 1 is a ridiculous coincidence that is usually only found in a fiction movie. Seattle is REALLY bad this season. Laying -6.5 on MNF is usually as taboo as it gets, but we can’t help ourselves here! Get Loot’s Den/Sea pick here!

Raiders vs. Chargers Odds, Analysis, Point Spread Pick

Raiders vs. Chargers Odds, Analysis, Point Spread Pick

The Las Vegas Raiders look to be a much-football team with addition of Davante Adams and others. The Los Angeles Chargers also beefed up at multiple key positions and are a legit Super Bowl contender this season. Get our LV/LAC Week 1 prediction here!

New York Giants vs. Tennessee Titans Odds & Picks

New York Giants vs. Tennessee Titans Odds & Picks

The Week 1 NFL matchup between the New York Giants and Tennessee Titans with a 5.5 spread is a typical example of bookies knowing they can get over on the general betting public based on recency bias. The G-Men have gotten better. The Titans not so much. Get Loot’s NYG/Ten value play here!

AFC South Best Bet: Colts vs. Texans

AFC South Best Bet: Colts vs. Texans

The 2022 Indianapolis Colts are solid on both sides of the ball and are considered to be Super Bowl contenders. Beating another team on the road and covering a -8 spread is no easy task though! Read Loot’s full game preview and get his Ind/Hou Week 1 NFL pick here!

Green Bay Packers vs. Minnesota Vikings Week 1 Game Pick

Green Bay Packers vs. Minnesota Vikings Week 1 Game Pick

We’d like to forewarn you that our office is split on the Week 1 Green Bay Packers vs. Minnesota Vikings game! There’s not really a ton of wagering value here. Check out EG’s Pack/Vikes game preview and get his GB/Min point spread prediction here!

49ers vs. Bears Analysis & Spread Prediction

49ers vs. Bears Analysis & Spread Prediction

Bettors should approach Week 1 with caution, as we don’t really have a strong take on what will happen with any team until we see them play, analyze and make assessments. The Niners vs. Bears game with a 7-point spread is sketchy at best, but Loot will give you his best shot at calling a winner.

Lay the Points: Steelers vs. Bengals ATS Bet

Lay the Points: Steelers vs. Bengals ATS Bet

The Pittsburgh Steelers start “Life without Ben Roethlisberger” against the Cincinnati Bengals in Week 1 against Joe Burrow, who has beaten them by double digits three times in a row. Get Jay’s Pit/Cin pick ATS before placing your bets!

Chiefs vs. Cardinals Spread & Total Predictions

Chiefs vs. Cardinals Spread & Total Predictions

With a bunch of new players on offense (JuJu Smith-Schuster/Marquez Valdez-Scantling/Skyy Moore) and being on the road, can the Kansas City Chiefs cover a -4.5 point spread against the Arizona Cardinals? Get Ted’s KC/AZ prediction here!